Source: International Congress 2016 – Asthma: mechanisms and biomarkers that promote clinical understanding
Disease area: Airway diseases, Respiratory infections

Abstract

Background: Intensive exercise may affect the innate immunity, influence inflammatory response and increase susceptibility to respiratory infections.Aim: To assess if exercise modifies expression of innate immune response molecules in peripheral blood leukocytes (PBL) of competitive athletes, asthmatics and healthy subjects.Methods: Study included 15 athletes (speed skaters and swimmers), 9 mild-to-moderate asthmatics (AC) and 7 healthy non-exercising subjects (HC).Treadmill exercise challenge was done and PBLs were isolated before, immediately after and 1 hour post-exercise. Following RNA isolation relative gene expression was assessed by qPCR and calculated using 2^{-D DCt} method with pre-exercise expression as reference.Results: Significant decrease in mRNA expression immediately post-exercise was observed for IL-1ra in athletes (mean decrease 72%;p<0.02) and HC (mean decrease 66%;p<0.05) and for HSPA1 in athletes (61%;p<0.01) and HC (58%;p=0.03). TNF-a gene expression decreased immediately after and 1 hour after exercise in athletes (63%;p<0.01 and 47%;p<0.05, respectively) and HC (56% and 48%; p<0.05). CD14 expression was significantly decreased in all groups at both time-points.Conclusions: Acute exercise decreases innate immune response in PBLs to similar extent in competitive athletes and healthy subjects.


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Marcin Maciej Kurowski (Lodz, Poland), Marcin Maciej Kurowski, Janusz Jurczyk, Malgorzata Pawelczyk, Aleksandra Szulc, Hubert Krysztofiak, Marek L. Kowalski. Treadmill exercise decreases expression of innate immunity molecules in peripheral blood leukocytes in competitive athletes, asthmatics and healthy subjects. Eur Respir J 2016; 48: Suppl. 60, 571

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