Source: International Congress 2016 – Asthma: mechanisms and biomarkers that promote clinical understanding
Disease area: Airway diseases

Abstract

Background: Periostin may be a useful biomarker of Th2-eosinophilic airway inflammation and has been linked to remodeling in asthma. However, the association between serum periostin and the magnitude of airway wall thickness remains unclear.Aims and objectives: We examine the relationship between serum periostin and airway geometry in asthma.Methods: Twenty-five steroid-naïve patients with asthma, 30 patients with asthma treated with inhaled corticosteroids, and 40 aged-matched healthy controls were studied. Serum periostin, lung function, and inflammatory cell counts in sputum were measured. Airway dimensions were assessed by computed tomography; wall area (WA), wall-to-total area ratio, wall thickness and luminal area.Results: Serum periostin levels were significantly elevated in steroid-naïve patients with asthma compared with controls (p<0.01) and steroid-treated patients with asthma (p<0.01). In steroid-naïve patients, serum periostin were correlated with airflow limitation and WA/body surface area (BSA) (r=0.71, p<0.01), and sputum eosinophil percentage (r=0.60, p<0.01). No significant correlations were observed between periostin and clinical variables in steroid-treated patients. Multivariate analysis showed that percent of predicted FEV₁, WA/BSA, and sputum eosinophils were independent factor for high serum periostin (p<0.05, respectively).Conclusion: Serum periostin may be a candidate for a novel biomarker for not only eosinophilic inflammation but as a marker for airway remodeling in steroid-naïve asthma.


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Citations should be made in the following way:
Makoto Hoshino (Atami, Japan), Makoto Hoshino, Junichi Ohtawa, Kenta Akitsu. Relationship between serum periostin and airway wall thickness in asthma. Eur Respir J 2016; 48: Suppl. 60, 567

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