Attenuation of bleomycin-induced pulmonary fibrosis by direct thrombin inhibition is accompanied by a reduction in connective tissue growth factor mRNA levels

D. C. J. Howell, A. O. Dunscombe, G. J. Laurent, R. C. Chambers (London, United Kingdom)

Source: Annual Congress 2001 - Mechanisms of acute and chronic lung injury
Session: Mechanisms of acute and chronic lung injury
Session type: Poster Discussion
Number: 1404
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. C. J. Howell, A. O. Dunscombe, G. J. Laurent, R. C. Chambers (London, United Kingdom). Attenuation of bleomycin-induced pulmonary fibrosis by direct thrombin inhibition is accompanied by a reduction in connective tissue growth factor mRNA levels. Eur Respir J 2001; 16: Suppl. 31, 1404

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cell specific gene transfer of hepatocyte growth factor reduces bleomycin-induced lung fibrosis by inhibition of partial EMT
Source: Annual Congress 2008 - Vascular and interstitial remodelling in chronic lung disease: therapeutic interventions on the horizon
Year: 2008

17(R)-resolvinD1 mediates a pathway involving the transcription factor c-Fos to reduce bleomycin-induced pulmonary fibrosis in mice.
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018




NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

High expression of telomerase/endothelin-1 increase replication and activation of vascular myofibroblasts in usual interstitial pneumonia/idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Pathogenesis of diffuse parenchymal lung disease
Year: 2010


Increased binding activity of hypoxia inducible factor (HIF)-1α to vascular endothelial growth factor (VEGF) promoter region mediates enhanced vascular permeability in the lung of cystic fibrosis (CF) patients
Source: Eur Respir J 2003; 22: Suppl. 45, 173s
Year: 2003

Simultaneous inhibition of CTGF and Autotaxin reduces lung fibrosis and improves lung function in mice
Source: Virtual Congress 2021 – Developments in biomarkers and treatment strategies for chronic lung diseases
Year: 2021


CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages
Source: Eur Respir J, 51 (3) 1702120; 10.1183/13993003.02120-2017
Year: 2018



Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

IL-11 promotes pulmonary vascular remodeling and lung fibrosis through the activation of endothelial to mesenchymal transition.
Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2020

PP216 – Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity
Source: ERS Lung Science Conference 2021
Year: 2021

Endothelin-1 induced connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Transient transgene expression of CTGF in the lung induces moderate and reversible fibrosis
Source: Eur Respir J 2002; 20: Suppl. 38, 378s
Year: 2002

MMP expression and abnormal lung permeability are important determinants of outcome in IPF
Source: Eur Respir J 2009; 33: 77-84
Year: 2009



A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice
Source: Eur Respir J 2012; 40: 1475-1482
Year: 2012



Electroporation mediated gene transfer of hepatocyte growth factor reduces bleomycin induced pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 729s
Year: 2005

Treprostinil effectively inhibits PDGF and TGF-ß1 induced extracellular matrix composition by IPF fibroblasts
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

Metformin attenuates bleomycin-induced pulmonary fibrosis in mice via IGF-1 suppression
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018

HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012

VEGF reduces pulmonary hypertension and vascular remodeling in pulmonary fibrosis through reduced endothelial apoptosis
Source: Annual Congress 2009 - Pulmonary circulation I
Year: 2009