Efficacy of the PDE4 inhibitor, BAY 19-8004, in a smoke-induced model of pulmonary inflammation in the guinea pig

M. F. Fitzgerald, D. Spicer, H. Lisle, N. Bowyer, R. G. Sturton, D. Minshall, B. Meshi, D. Ionescu, M. T. Shrad, J. C. Hogg (Stoke Poges, United Kingdom; Vancouver, Canada)

Source: Annual Congress 2001 - New treatments for asthma and COPD: PDE4 inhibitors and anti-IGE
Session: New treatments for asthma and COPD: PDE4 inhibitors and anti-IGE
Session type: Poster Discussion
Number: 339
Disease area: Airway diseases

Congress or journal article abstract

Rating: 5
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. F. Fitzgerald, D. Spicer, H. Lisle, N. Bowyer, R. G. Sturton, D. Minshall, B. Meshi, D. Ionescu, M. T. Shrad, J. C. Hogg (Stoke Poges, United Kingdom; Vancouver, Canada). Efficacy of the PDE4 inhibitor, BAY 19-8004, in a smoke-induced model of pulmonary inflammation in the guinea pig. Eur Respir J 2001; 16: Suppl. 31, 339

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Efficacy of the selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in a rat model of neutrophilic lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

The selective PDE4-inhibitor AWD 12-281 inhibits LPS-induced neutrophilia in domestic pig lung, an animal model of COPD: comparison with steroids
Source: Eur Respir J 2001; 18: Suppl. 33, 160s
Year: 2001

A selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in guinea-pig antigen challenge and ferret emesis models
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

Effect of phosphodiesterase 4 (PDE-4) inhibitor – rolipram with or without co-administration of dexamethasone on experimental asthma - guinea pig model
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

The effect of an oral phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in primate asthma models
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

Roflumilast N-oxide, a PDE4 inhibitor, curbs bleomycin-induced lung fibroblast activation in vitro
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Roflumilast but not methylprednisolone inhibited cigarette smoke-induced pulmonary inflammation in guinea pigs
Source: Eur Respir J 2006; 28: Suppl. 50, 663s
Year: 2006

AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced [DCquote]early phase“ bronchoconstriction in sensitized guinea pigs
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

AZD7624, an inhaled p38 inhibitor for COPD, attenuates lung and systemic inflammation after LPS Challenge in humans
Source: International Congress 2015 – Advances in the future treatment of COPD
Year: 2015


The PDE4 inhibitor roflumilast reduced bleomycin-induced pulmonary fibrotic and vascular remodeling in mice in vivo
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001

Effect of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor (PDE4i) on markers of inflammation in COPD patients
Source: International Congress 2019 – Advances in COPD pharmacology
Year: 2019

Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Year: 2007


Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation
Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents
Year: 2017



Inhibition by roflumilast vs cilomilast of pulmonary leukocyte accumulation and TNFα release in a rat model of LPS-induced pulmonary neutrophilia
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Effects of pendrin inhibitor (PDI_C01) in vitro, and in vivo models of lipopolysaccharide-induced airway inflammation.
Source: International Congress 2019 – Biomarkers, laboratory findings and pre-clinical data in acute respiratory failure
Year: 2019


A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury
Source: Eur Respir J 2003; 22: 20-27
Year: 2003



CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Treatment with proteinase inhibitor, BbCI, modulates inflammatory response, mechanic alterations, and remodeling on elastase-induced emphysema in mice
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012