Source: Annual Congress 2002 - Drug resistance
Disease area: Respiratory infections

Abstract

The problem of drug-resistance in tuberculosis(TB) is gradually increasing in many parts of our country and throughout the world.
To contribute the data of our country,the records of drug-resistant TB patients were evaluated during a six year period retrospectively.Among a total number of 934 patients 531(56.7%) had culture positivity,in 453(85.3%) of them drug sensitivity test results had been recorded.There were 394(87.0%) new and 59(13.0%) previously treated patients.Of 97(21.4%) patients,who had resistance to at least one anti-TB drug,total initial resistance rate was 80.4%(n=78).Initial resistance rates for each anti-TB drugs were as follows;for isoniazid(H) 5.6%,for rifampicin(R) 6.1%,for streptomycin(S) 9.9% and for ethambuthol(E) 6.3%.Total acquired resistance rate was 19.6%(n=19).Acquired resistance rates for each anti-TB drugs were as follows;for H 15.3%,for R 15.3%,for S 18.6%,for E 11.9%.Initial and acquired multi-drug resistant tuberculosis(MDRTB) rates were 1.2% and 8.5% respectively.Resistance was frequent in female patients(p=0.025).A significant relation was found between close contacs and drug resistance(p=0.029).Generaly,rates of patient adherence and treatment success were 89.1%-86.1% in our dispensary.
As a conclusion,in this study,the rates of acquired resistances seperatly and MDRTB were lower than the data of our country,while the rate of initial resistance was similar.This may be related to the referance of these patients to highly specialized centers by the endorsement of National Tuberculosis Control Program.In addition,there may be a relation with the high rates of patient adherence and treatment success in our dispensary.

Rating:

Share or cite this content

Citations should be made in the following way:
I. Coskunol, S. Alptekin, M. Aydin, D. Tatar (Izmir, Turkey). Resistance pattern of tuberculosis patients enrolled to Izmir esrefpasa tuberculosis dispensary between 1996-2001. Eur Respir J 2002; 20: Suppl. 38, 3843

Member's Comments

No comment yet.

Related content which might interest you: Evaluation of 934 tuberculosis patients enrolled to esrefpasa tuberculosis dispensary (1996-2001) Source: Eur Respir J 2002; 20: Suppl. 38, 364s Year: 2002 The evaluation of childhood tuberculosis cases followed up at Izmir Esrefpasa Tuberculosis Dispensary between 1995-2007 Source: Annual Congress 2008 - Specific tuberculosis management problems in children and adolescents Year: 2008 Active tuberculosis in children in close contact with smear-positive cases of pulmonary tuberculosis in Sofia (Bulgaria) during the period 2007-2009 Source: Annual Congress 2010 - Tuberculosis in children Year: 2010 The retrospective analysis of cases with extrapulmonary tuberculosis diagnosed at (Izmir) Esrefpasa tuberculosis dispensary between 1995-2000 Source: Eur Respir J 2001; 18: Suppl. 33, 309s Year: 2001 The retrospective analysis of tuberculosis in children followed-up at Izmir Esrefpasa dispensary between 1995-2000 Source: Eur Respir J 2001; 18: Suppl. 33, 469s Year: 2001 Performance of regional tuberculosis dispensaries in a province of Turkey in pre-DOTS-era (1989-2002) Source: Annual Congress 2006 - Epidemiology and control of tuberculosis Year: 2006 Epidemiology of tuberculosis (TB) in Poland in the period 1994-2003 Source: Eur Respir J 2005; 26: Suppl. 49, 191s Year: 2005 Assessment of tuberculosis cases observed in Manisa Tuberculosis Dispensary between 1989 and 2003 Source: Eur Respir J 2004; 24: Suppl. 48, 419s Year: 2004 Treatment of tuberculosis in Hungary in 2003 Source: Eur Respir J 2004; 24: Suppl. 48, 652s Year: 2004 Tuberculosis contact – impact on children’s affliction with tuberculosis, in Belgrade from 1992-2003 compared to the period 1976-1991 Source: Eur Respir J 2004; 24: Suppl. 48, 198s Year: 2004 Extra-pulmonary tuberculosis in the district of Cluj, Romania from 1999 to 2004 Source: Eur Respir J 2005; 26: Suppl. 49, 189s Year: 2005 Characteristics of XDR-TB patients in Israel: 2000-2010 Source: Annual Congress 2011 - Risk factors and treatment outcomes in multidrug- and extensively drug-resistant tuberculosis Year: 2011 Treatment outcomes of MDR-TB patients notified in Romania during 2005-2007 Source: Annual Congress 2011 - Risk factors and treatment outcomes in multidrug- and extensively drug-resistant tuberculosis Year: 2011 Treatment default rates and patient characteristics in Umraniye tuberculosis dispensary, Istanbul (1997-2006) Source: Eur Respir J 2007; 30: Suppl. 51, 423s Year: 2007 Pulmonary tuberculosis (PT) among Kosovo's refugees who were treated from July 1999, til the end of 2001, in the department for tuberculosis (TB) in the clinic for pulmonary diseases Nis-Yugoslavia Source: Eur Respir J 2002; 20: Suppl. 38, 361s Year: 2002 Epidemiology of smear-negative pulmonary tuberculosis in Sardinia (Italy) from 2000 to 2009: Role of ex-adiuvantibus treatment Source: Annual Congress 2011 - Respiratory epidemiology: prevalence, incidence and remission Year: 2011 Drug resistance of mycobacterium tuberculosis isolates in Serbia over five-year period (2001-2005) Source: Annual Congress 2008 - Clinical epidemiology of tuberculosis Year: 2008 Treatment outcomes and deaths among multidrug-resistant tuberculosis (MDR-TB) patients in Gomel region, Belarus – 2009-2010 Source: Annual Congress 2013 –Drug-resistant tuberculosis: new clinical and public health insights Year: 2013 Management of MDR and rifampicin-resistant TB cases in Italy, 1995-1999 Source: Eur Respir J 2001; 18: Suppl. 33, 513s Year: 2001 Study of drug-resistant tuberculosis in Plovdiv region, Bulgaria - 1989-2003 Source: Eur Respir J 2005; 26: Suppl. 49, 651s Year: 2005