Source: Annual Congress 2002 - Drug resistance
Disease area: Respiratory infections

Abstract

The incidence of lung tuberculosis is of 143/100.000, in Romania, and the cases of lung tuberculosis with positive Mycobaterium tuberculosis elimination resulted from new cases and relapses. Moreover, in our country, secondary chemoresistance is begining to reach worried procents.
We have studied 100 chonically patients with tuberculosis, who had secondary chemoresistance , which were hosted in Pneumophisiology Clinic, Cluj-Napoca, Romania, during 1999-2000. We have analyzed the weight on genders (68% males), the repartition on age ( a group of 21-30 years-21% and a goup of 41-50 years-31%), their kind of work (41%-not woking, 24%-pensioners, 22%-workers), the use of noxes (40 cases-smokers, 30 cases alcohol users); associate diseases, medication-individualized therapeutical schema, intolerance, and the level of secondary chemoresistance: 60%-monoresistance, 29%-biresistance, 13%-multi drug resistance. Using this information, we have established the main reasons of the therapeutical failure which leads to secondary chemoresistence: non-compliance and associated pathology. At the end of the treatment we found: 1% cured patients, 3% with negative sputum, 65% still remains with positive M.t elimination and 31% were died.

Rating:

Share or cite this content

Citations should be made in the following way:
C. M. Pop, M. A. Man, M. A. Goron, C. D. Zamora, D. Homorodean (Cluj-Napoca, Romania). The main causes which leads to secondary chemoresistance. Eur Respir J 2002; 20: Suppl. 38, 3841

Member's Comments

No comment yet.

Related content which might interest you: The main causes which are responsible for secondary chemoresistance of Mycobacterium tuberculosis Source: Eur Respir J 2003; 22: Suppl. 45, 524s Year: 2003 The development of mutant P53 characterized by lung cancers contributes to their primary and acquired multi-drug resistance to chemotherapy Source: Eur Respir J 2005; 26: Suppl. 49, 457s Year: 2005 The main causes which lead to immediate and belated failure in tuberculosis Source: Eur Respir J 2005; 26: Suppl. 49, 141s Year: 2005 Anthracosis of lung: evaluation of potential underlying causes Source: Eur Respir J 2005; 26: Suppl. 49, 304s Year: 2005 What are the main mechanisms of oncogenic addiction? Source: New biomarkers, molecules and therapeutic sequences for non small cell lung carcinoma in the era of precision medicine Year: 2019 Modified sensitivity of alveolar cells to TRAIL-mediated apoptosis: a mechanism involved in emphysema pathogenesis with a potential impact on cancer therapy research Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury Year: 2009 Does acute phase protein alpha1-antitrypsin modulate apoptosis-autophagy crosstalk resulting in resistance of NSCLC cells to cancer drugs? Source: Virtual Congress 2021 – Biology of lung cancer: preclinical and translational research Year: 2021 miR-184 mediates hyperoxia-induced injury by targeting cell death and angiogenesis signalling pathways in the developing lung Source: Eur Respir J, 58 (3) 1901789; 10.1183/13993003.01789-2019 Year: 2021 The effect of new drug-resistance antisense gene on multidrug resistance mechanism of drug-resistant human small cell lung cancer cells Source: Eur Respir J 2007; 30: Suppl. 51, 715s Year: 2007 Mechanisms leading to the bronchorelaxant synergy of ICS/LABA/LAMA combination Source: International Congress 2019 – Advances in asthma pharmacology Year: 2019 TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal Source: International Congress 2018 – Lung cancer: novel molecular markers and mechanisms Year: 2018 Inhibition of insulin-like growth factor type I (IGF-I) gene in A549 human lung cancer cell line enhances cell apoptosis and causes phenotype changes relevant to increased tumor susceptibility to immune system Source: Eur Respir J 2007; 30: Suppl. 51, 715s Year: 2007 Epigenetic deregulated translation control of C/EBP-alpha leads to increased mesothelioma cell proliferation Source: Annual Congress 2011 - Pleural and mediastinal malignancies: management and rare clinical cases Year: 2011 PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology Year: 2019 Activation of proteolytic mechanisms in response to inflammatory stimuli: a possible role in the development of the aleolocapillary barrier damage Source: Eur Respir J 2003; 22: Suppl. 45, 458s Year: 2003 Molecular mechanisms are involved in ethanol mediated lung endothelial barrier dysfunction Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury Year: 2011 A complex case of respiratory failure secondary to an unusual lung pathological finding in a patient with COVID-19 Source: Virtual Congress 2021 – CCC Respiratory critical care Year: 2021 Low apoptosis rate as a reason of local immune cell accumulation in interstitial lung diseases (ILD). The role of cytokine network Source: Eur Respir J 2006; 28: Suppl. 50, 826s Year: 2006 Inhibition of hypoxia-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN Source: Annual Congress 2011 - Lung cancer: molecular pathology and functional genomics Year: 2011