The experience of overcome of Mcb.tuberculosis resistance to antituberculosis drugs
M. V. Fedorova, E. Y. Stoukalina, K. A. Lipsky, S. A. Zhilina, A. P. Duntau, E. V. Medvedeva, E. M. Karpov, V. G. Kononenko, L. V. Alekseev (Novosibirsk, Russia)
Source: Annual Congress 2002 - Drug resistance
Session: Drug resistance
Session type: Poster Discussion
Number: 3831
Disease area: Respiratory infections
Abstract Drug resistance is one of the main reasons of TB process progressing and lethal outcome in the end.Elaboration of new drugs able to overcome the resistance of Mcb. Tuberculosis to anti-TB drugs is of great interest. We have studied the efficiency of new immunostimulator [dsquote]glutoxim[dsquote] in combination with anti-TB drugs in drug resistance overcome. There were 18 patients with drugs resistant pulmonary tuberculosis, 13 male and 5 female from 20 to 68 years old. In all cases Tb process was cavernous, in 14 cases two-sided. The most common resistance was to Streptomycin- in 14 cases (77.8% of patients), to Rifampicin- in 11 cases(61.1%), to Canamycin– in 8(44.4%), to Ethambutol- 8(44.4%), to Izoniazid-7(38.9%), to Micobytin- in 5(27.8%).[dsquote]Glutoxim[dsquote] was used for a month in combination with 4-5 anti-TB drugs .As the result the overcome of resistance to Isoniazid was achieved in 5 cases from 7 (71.4%), to Canamycin- in 4 cases from 8( 50%), to Streptomycin- in 3 cases from 14 (21.4%), to Ethambutol- in 4 cases from 8 (50%). Resistance to Rifampicin B group was not overcome. The increase of sensitivity to Streptomycin was registered in 9 patients more. Conclusion. New immunostimulator [dsquote]glutoxim[dsquote] can be used to reverse the resistance of Mcb. Tuberculosis to anti-TB drugs. This study has to be continued.
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M. V. Fedorova, E. Y. Stoukalina, K. A. Lipsky, S. A. Zhilina, A. P. Duntau, E. V. Medvedeva, E. M. Karpov, V. G. Kononenko, L. V. Alekseev (Novosibirsk, Russia). The experience of overcome of Mcb.tuberculosis resistance to antituberculosis drugs. Eur Respir J 2002; 20: Suppl. 38, 3831
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