Source: Annual Congress 2002 - Drug resistance
Disease area: Respiratory infections

Abstract

The frequency of development acquired drug resistance was analyzed in 109 successful treated patients with newly detected sputum positive pulmonary tuberculosis. In an intensive phase of treatment 46 patients have applied treatment with inclusion 4-5 antituberculous drugs in a mode: 4HRSZ(E), 4HRS(S3)Z(Z3)E(E3). In a supporting phase we used 2-3 drugs: 2H(H3) R (R3), 2H(H3)R(R3)Z(Z3). Efficacy of treatment was high: sputum conversion we observed in 99,1 % of patients within 2,3 months. Acquired drug resistance was developed in 7 (6,4 %) from 109 patients during first 2 months of treatment. Drug resistance to R was determined in 0,9% patients, to H - in 1,8%, to S - in 0,9%, to HS - in 1,8%, to HR - in 0,9%. Conclusion. Drug resistance has developed in some patients despite of successful treatment with application 4-5 drugs. More often resistance was defined to H, R, S. In a result, it will enable to predict acquired drug resistance in persons with relapses of tuberculosis for adequate of their repeated treatment. Therefore it is expedient in process of chemotherapy to determine drug resistance to used drugs, that will allow in time to correct of treatment.

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N. A. Litvinenko, V. M. Petrenko (). Frequency of development acquired drug resistance in successful treated patients with newly detected pulmonary tuberculosis. Eur Respir J 2002; 20: Suppl. 38, 3827

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