Source: Annual Congress 2002 - Clinical and social reflections of tubercular disease

Abstract

Vascular endothelial growth factor (VEGF) is a mediator with potent angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. Intense angiogenesis has been found in active pulmonary tuberculosis lesions.We determined serum VEGF levels in 44 patients with active pulmonary tuberculosis, 24 patients with inactive pulmonary tuberculosis and 20 healthy subjects in order to investigate the role of VEGF in the pathogenesis of tuberculosis.VEGF levels were increased in active pulmonary tuberculosis patients (mean±]SD 598.03±]298.25 pg/ml) as compared to both inactive pulmonary tuberculosis patients (296.98±]115.31 pg/ml) and control subjects (339.67±]74.65 pg/ml). The increase of VEGF observed in active tuberculosis patients were statistically significant when compared with other two group (p<0.001 for both). Serum VEGF levels were statistically different between before treatment and after treatment in 10 patients followed from diagnosis to the end of treatment (p<0.01). In conclusion, serum VEGF levels were increased in active pulmonary tuberculosis patients. Elevated serum VEGF may result in tissue angiogenesis, and may have a role in the progression of pulmonary tuberculosis lesions.

Rating:

Share or cite this content

Citations should be made in the following way:
F. Alatas, O. Alatas, M. Metintas, A. Ozarslan, S. Erginel, H. Yildirim (Eskisehir, Turkey). Vascular endothelial growth factor levels in active pulmonary tuberculosis. Eur Respir J 2002; 20: Suppl. 38, 3816

Member's Comments

No comment yet.

Related content which might interest you: Serum levels of vascular endothelial growth factor in patients with active pulmonary tuberculosis Source: Eur Respir J 2006; 28: Suppl. 50, 341s Year: 2006 Serum levels of vascular endothelial growth factor in the differential diagnosis of pulmonary tuberculosis Source: Eur Respir J 2002; 20: Suppl. 38, 210s Year: 2002 Vascular endothelial growth factor (VEGF) and airway inflammation in COPD. Correlation with pulmonary function Source: Eur Respir J 2006; 28: Suppl. 50, 653s Year: 2006 Vascular endothelial growth factor (VEGF) and bronchial wall remodelling in asthma Source: Annual Congress 2004 - Genetics and molecular mechanisms of COPD and asthma Year: 2004 Bioavailability of vascular endothelial growth factor (VEGF)? A role in pulmonary fibrosis? Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation Year: 2012 The clininical value of vascular endothelial growth factor (VEGF) in the development of lung sarcoidosis. Source: International Congress 2018 – Sarcoidosis: from basic research to patient outcomes Year: 2018 Circulating vascular endothelial growth factor and osteoporosis in patients with COPD Source: Annual Congress 2010 - COPD: systemic inflammation and comorbidities Year: 2010 A role for vascular endothelial growth factor (VEGF) in fibrosis? Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung Year: 2009 Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo Source: Eur Respir J 2011; 38: 939-946 Year: 2011 Nerve growth factor expression and function in pulmonary arterial hypertension Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension Year: 2010 Production of a novel isoform of vascular endothelial growth factor (VEGF) by the normal human lung Source: Eur Respir J 2006; 28: Suppl. 50, 822s Year: 2006 Imbalance between vascular endothelial growth factor and endostatin in emphysema Source: Eur Respir J 2003 Oct 01;22(4):609-612 Year: 2003 Increased binding activity of hypoxia inducible factor (HIF)-1α to vascular endothelial growth factor (VEGF) promoter region mediates enhanced vascular permeability in the lung of cystic fibrosis (CF) patients Source: Eur Respir J 2003; 22: Suppl. 45, 173s Year: 2003 PTEN reduces vascular endothelial growth factor–mediated vascular permeability in asthma Source: Eur Respir J 2005; 26: Suppl. 49, 581s Year: 2005 Dual mechanism of platelet-derived growth factor (PDGF)-receptor: Contribution of vascular response to the pathogenesis of pulmonary hypertension (PH) Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease Year: 2015 Serum levels of vascular endothelial growth factor in lung cancer patients Source: Eur Respir J 2004; 24: Suppl. 48, 77s Year: 2004 Vascular endothelial growth factor (VEGF) levels in induced sputum and plasma in asymptomatic and COPD smokers. Correlation with airway and systemic inflammation Source: Eur Respir J 2006; 28: Suppl. 50, 652s Year: 2006 Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients Source: Eur Respir J 2002; 20: Suppl. 38, 1s Year: 2002 Vascular endothelial growth factor (VEGF) , a specific marker of angiogenesis, is increased in asthmatic airways following allergen challenge Source: Eur Respir J 2004; 24: Suppl. 48, 227s Year: 2004