Source: Annual Congress 2002 - Clinical and social reflections of tubercular disease

Abstract

Severe pulmonary tuberculosis (PTB) is sometimes complicated with deep venous thrombosis (DVT). We have searched for some possible hemostatic disturbances, which are predisposing factors for venous thrombosis, in patients with PTB.
Coagulation and platelet function tests have been studied in 45 patients with active PTB and 20 healthy control volunteers before therapy and findings were compared with 30th day results.
Analysis in patients with active PTB showed anemia, leucocytosis, thrombocytosis, elevation in plasma fibrinogen, factor VIII, plasminogen activator inhibitor 1 (PAI-1) with depressed antithrombin III (AT III) and protein C (PC) levels. On the 30th day of treatment, anemia, leucocytosis and thrombocytosis were improved. Fibrinogen and factor VIII levels decreased to normal levels, PC and AT III levels increased to normal levels whereas there was no difference in PAI-1 levels. We couldn't find an activated protein C resistance. Platelet aggregation studies demonstrated increased platelet activation. However, DVT was not detected in patients during the follow up period.
Decreased AT III, PC and elevated plasma fibrinogen levels and increased platelet aggregation appear to induce hypercoagulable state seen in PTB and improve with treatment.

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E. Kunter, O. Turken, M. Sezer, E. Solmazgul, K. Cerrahoglu, E. Bozkanat, A. Ozturk, A. Ilvan (Istanbul, Turkey). Hemostatic changes in active pulmonary tuberculosis. Eur Respir J 2002; 20: Suppl. 38, 3815

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