Source: Annual Congress 2002 - Oncology imaging: CT, MRI and PET
Disease area: Airway diseases

Abstract

Chronic obstructive lung disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. COPD is a disease state characterized by airflow limitation that is not fully reversible and also progressive.
For the diagnosis and assessment of COPD, pulmonary function tests (PFT), arterial blood gas (ABG) and diffusing capacity (DC) measurements are corner stones. Currently, high resolution computed tomography (HRCT) has already been used to detect severity, extention of the paranchimal destruction and anatomic distribution of the disease. In this study, the purpose is to analyzed correlation between high resolution computed tomography and lung function tests in diagnosis of COPD.
Thirty clinically stable patients were exposed to high resolution computed tomography scanning after carrying out their PFT, DC and ABG. Twenty five were men and five were women. The mean age was 63.27 year (40-75). Qualitative evaluation based on visual scoring method in HRCT. Our patients were distinct two major groups (chronic bronchitis (19/30) and emphysema (11/30)). When we compared all patients without made two main group, there were highly significant negative correlation between indexes of airflow obstruction (FEV1 %, L, p <0.001; FEF25-75 %, L and PEF %, p <0.005) and COPD stage. In emphysematous group we found highly significant correlation between visual score and disease stage (p <0.001), and also we found very strong correlation between visual score and DLCO (%, L), DLCO/VA (%, L) measurements (p <0.001). In two patients emphysematous changes were demonstrated in HRCT without spirometric or other physiologic measurement abnormality.
With these values, we conclude at clinical practice HRCT demonstrate morphological changes in a stage before symptoms develop in emphysematous patients.

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Citations should be made in the following way:
H. Lakadamyali, S. Alpar, H. Lakadamyali, H. Erturk, B. Kurt (Alanya-Antalya, Turkey). Correlation of high resolution computed tomography findings and pulmonary function tests, arterial blood gas, diffusing capacity measurements in COPD. Eur Respir J 2002; 20: Suppl. 38, 3766

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