Source: Annual Congress 2002 - Oncology imaging: CT, MRI and PET
Disease area: Thoracic oncology

Abstract

In the past decade some new tumor directed tracers have also been used in lung cancer evaluation. We investigated 69 patients with lung cancer using different tumor targeting tracers in order to assess the diagnostic sensitivity in primary lung cancer detection. Group 1 consisted of 25 patients (22 pts with NSCLC and 3 ith SCLC) where tumor associated monoclonal antibodies, HMFG1 and AUA1 labeled with 99mTc, were performed. In the second group 20 patients were injected with 74 MBq of 99mTc-sestamibi. In all patietns anterior and posterior planar thoracic images were acquired. In the case of positive finding, images were processed by drawing region of interest around the tumor and contra lateral position and tumor to non-tumor (T/ NT) ratios were calulated. In 10/22 (45%) patients in group 1 the scan was found to be true positive, 13/22 patients were false negative and 1/3 patients with SCLC was false positive. The mean T/NT ratio was found 1.7±]0.36. In group 2 of pts 18/20 (90%) were true positive and mean T/NT ratio was 1.59±]0.15 (p>0.05). In the third group 20/24 (83%) patients were found true positive. Mean T/NT ratio (1.6±]0.29) did not significantly differ from groups 1 and 2.
201-Tl and 99mTc-sestamibi scintigraphy showed better diagnostic sensitivity in primary lung cancer detection than radioimmunoscintiraphy with monoclonal antibodies. T/NT ratios did not significantly differ for all three tracers.

Rating:

Share or cite this content

Citations should be made in the following way:
V. Obradovic, S. Pavlovic, D. Sobic-Saranovic, D. Jovanovic, G. Radosavljevic (Belgrade, Yugoslavia). Detection of primary lung cancer by tumor targeting imaging. Eur Respir J 2002; 20: Suppl. 38, 3764

Member's Comments

No comment yet.

Related content which might interest you: Scintigraphy with 99mTc-depreotide has a high sensitivity in detecting lung cancer Source: Annual Congress 2007 - Diagnosis and staging of lung cancer: existing and new techniques Year: 2007 Early detection of lung cancer Source: Annual Congress 2013 –Biological signatures in thoracic oncology Year: 2013 An analysis of EGFR expression and tumour imaging in non-small cell carcinomas of lung Source: Annual Congress 2011 - Imaging, functional evaluation and staging for lung cancer patients Year: 2011 Expression of βig-h3 as a marker of local tumor invasion in non-small cell lung cancer Source: Eur Respir J 2006; 28: Suppl. 50, 770s Year: 2006 Does expression of betatubulin 3 correlate between primary non small cells lung cancer tumor and metastases? Source: Annual Congress 2009 - Treatment of lung cancer Year: 2009 Contribution of tumor markers to pretreatment staging of operable lung cancer Source: Eur Respir J 2003; 22: Suppl. 45, 360s Year: 2003 Synchronous primary lung cancer with three separate tumors Source: Annual Congress 2007 - Lung neoplasms Year: 2007 Clonality of multifocal nonsmall cell lung cancer: implications for staging and therapy Source: Eur Respir J 2012; 39: 1437-1442 Year: 2012 Detection of unusual distant metastases or secondary malignancies in the routine staging of primary lung cancer with 18F-FDG-PET/CT Source: Annual Congress 2009 - Old and new: technique and pathology Year: 2009 Cyst-related primary lung malignancies: an important and relatively unknown imaging appearance of (early) lung cancer Source: Eur Respir Rev, 27 (150) 180079; 10.1183/16000617.0079-2018 Year: 2018 Narrow band imaging (NBI) for early lung cancer detection Source: Annual Congress 2006 - Hot technologies in bronchoscopy and thoracoscopy Year: 2006 Second primary lung cancer Source: Eur Respir J 2004; 24: Suppl. 48, 73s Year: 2004 Management of a large tumour Source: Annual Congress 2005 - Oncology Grand Round: an interactive session Year: 2005 Detection of lung malignancy using 99mTc/Tektrotyd Source: Annual Congress 2008 - Biology and diagnosis of thoracic tumours Year: 2008 Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation Source: Eur Respir J 2011; 37: 624-631 Year: 2011 Analysis of the patients with primary lung cancer Source: Eur Respir J 2007; 30: Suppl. 51, 562s Year: 2007 Tumor specific MUC1 expression in operable lung cancer correlates with improved survival Source: Eur Respir J 2005; 26: Suppl. 49, 459s Year: 2005 A novel biologic classification of non-small cell lung cancer Source: Annual Congress 2005 - New insights into prognosis in thoracic surgical oncology Year: 2005 Should there be a specific management for large cell neuroendocrine carcinoma? Source: Annual Congress 2005 - Neuroendocrine tumours of the lung Year: 2005 Treatment modalities in lung cancer patients with brain metastasis Source: Annual Congress 2012 - Treatment of lung cancer Year: 2012