Source: Annual Congress 2002 - Oncology imaging: CT, MRI and PET
Disease area: Thoracic oncology

Abstract

Thallium choride-201 (Tl-201) and technetium-99m hexakis 2-methoxy isobutylisonitrile (99mTc-MIBI) are indicators of tumor viability and they do not accumulate in necrotic tissues. The aim of this study was to evaluate frequency of tumor necrosis in patients with lung cancer by Tl-201 and 99mTc-MIBI scinitgraphy. We studied 44 patients with histollogicaly proven lung cancer divided in two groups: 20 patients in group I (4 pts with small cell lung cancer-SCLC, and 16 pts with non-small cell lung cancer -NSCLC) were injected with 74 MBq of Tl-201, while in Group II 24 patients (5 pts with SCLC and 19 pts with NSCLC) were injected with 370 MBq of 99mTc-MIBI. Thoracic scintigraphy in anterior and posterior projection were acquired in both groups. In case of positive findings, tumor to nontumor (T/NT) ratio was calculated.Results: In Group I 18/20 (90%) patients were found true positive on Tl-201 scinitgraphy, and in 4 of 18 patients (22%) focal uptake with central necrosis was present. In Group II 20/24 (83%) of patients were found true positive on 99mTc-MIBI chest scinitgraphy, while tumor necrosis was found in 5/20 (25%) true positive scinitgrams. No significance differences in mean T/NT ratio between Group I (Tl-201) and Group II (99mTc-MIBI) were detected (1.63 ±] 0.32 vs. 1.61 ±] 0.30,p>0.05, respectively).Conclusion: Our results indicate that primary lung cancer was detected by thoracic scinitgraphy with T-201 and 99mTc-MIBI in 38/44 (86%) patients, and tumor necrosis in 20% (9/44) of them. Both scinitgraphies are noninvasive and effective for the detection of tumor necrosis that may influence the response to treatment of patients with lung cancer.

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D. P. Sobic-Saranovic, S. Pavlovic, G. Radosavljevic-Asic, N. Kozarevic, D. Jovanovic, V. Obradovic, V. Bosnjakovic (Belgrade, Yugoslavia). Tumor necrosis of lung cancer: detection by Tl-201 and 99mTc-MIBI scinitgraphy. Eur Respir J 2002; 20: Suppl. 38, 3763

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