Source: Annual Congress 2002 - Interstitial lung disease
Disease area: Airway diseases, Interstitial lung diseases

Abstract

Systemic sclerosis (SSc) is accompanied by influx of activated phagocytes into distal airways. These cells release oxidants including H₂O₂ that may be exhaled or induce damage to surrounding tissues with formation of thiobarbituric acid reactive substances (TBARs). We tested whether patients with SSc exhale more H₂O₂ and this correlates with markers of systemic oxidative stress and clinical parameters. H₂O₂ was measured in expired breath condensate of 27 SSc patients and 27 matched healthy controls. Baseline and fMLP-induced whole blood chemiluminescence, serum TBARs concentration were determined as measures of systemic oxidative stress. Exhaled H₂O₂, serum TBARs levels, baseline and fMLP –induced whole blood chemiluminescence (absolute light emission) were 3.5-, 20.5-, 1.4- and 2.3- times higher (p<0.001) in patients with SSc than in healthy controls. Current treatment with cyclophosphamide and prednisone did not decrease exhaled and circulatory markers of oxidative stress but was inversely correlated with H₂O₂ exhalation (r= -0.62, p<0.001). H₂O₂ levels correlated (p<0.05) with disease duration (r=0.38), time from the first Raynauds episode (r=0.44) in the whole SSc group while in patients treated with cyclophosphamide and prednisone (n=10) the association with lung involvement (r=0.72), forced vital capacity (r= -0.76), baseline chemiluminescence (r=0.72) and absolute light emission (r=0.79) was found (p<0.05).
We conclude SSc patients express increased H₂O₂ exhalation that correlates with selected clinical parameters and elevated markers of systemic oxidative stress.

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M. Luczynska, U. Szkudlarek, B. Dziankowska-Bartkowiak, E. Waszczykowska, M. Kasielski, A. Sysa-Jedrzejowska, D. Nowak (Lodz, ; Lodz, Poland). Elevated exhaled and circulatory markers of oxidative stress in patients with systemic sclerosis. Eur Respir J 2002; 20: Suppl. 38, 3756

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