Source: Annual Congress 2002 - Thoracic oncology: diagnosis and prognosis
Disease area: Thoracic oncology

Abstract

There is increasing evidence for superiority of FDG-PET over conventional imaging techniques for lung cancer recurrence. We report our experience with PET in 60 consecutive patients with suspected lung cancer recurrence after curative first-line treatment. A total of 65 PET scans werde done. Recurrence was diagnosed in 51 patients, confirmed by pathology in 41 cases. Visual PET analysis identified tumor recurrence in 49/51 (96 %) patients. PET was true-negative in 12/14 (86 %) cases. In tumor recurrence, FDG-uptake (SUV) was 10.9 + 5.2, compared to a SUV of 2.2 + 0.4 (p<0.001) in patients with complete remission. For visual PET analysis sensitivity, specificity and accuracy for detection of tumor recurrence were 96 %, 86 % and 94 %. Using a threshold SUV of 3.25, the corresponding values were 96 %, 100 % and 97 %, respectively. Our data confirm the high accuracy of FDG-PET in diagnosis of lung cancer recurrence. Semiquantitative PET analysis increases specificity without loss in sensitivity.

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D. Hellwig, A. Gröschel, G. W. Sybrecht, C. M. Kirsch, D. Ukena (Homburg, Germany). Accuracy of positron emission tomography with 18F-fluoro-deoxyglucose (FDG-PET) in diagnosis of recurrence of lung cancer after curative first-line therapy: visual and semiquantitative PET analysis. Eur Respir J 2002; 20: Suppl. 38, 3725

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