Source: Annual Congress 2002 - Thoracic ultrasound and photodynamic therapy
Disease area: Thoracic oncology

Abstract

Material and Method:
146 patients (106 male 40 female) aged 44-88 years (mean 64.8) with inoperable bronchopulmonary cancer, either because of extent of tumour or general condition, entered into a prospective study. 85% had received chemo/radiotherapy prior to referral. Pre PDT investigations consisted of standard clinical and functional testing plus imaging examination to assess extent of tumour and staging. PDT protocol was intravenous administration of 2mg/kg body weight of photosensitiser (Photofrin) followed 24-72 hours later by bronchoscopic illumination using 630nm light.
Results and Conclusions:
11 patients had stage I or Tis tumour. The remainder were 118 (stage III) and 17 (stage IV). There was no PDT related mortality. There was mild photosensitivity reaction in 3.6%. Patient satisfaction was 100%. Symptomatic improvement was recorded in 92%. FVC and FEV1 improved by a mean of 0.4L + 0.2L respectively. Performance status improved significantly. All patients with early stage tumour are alive (the longest for 101 months). In stage III and IV, 90% of patients have died. Multivariant analysis showed age, sex and histology did not influence survival. Influence of histological stage and WHO performance status on survival was statistically significant. We concluded that PDT has an important therapeutic role in inoperable bronchial cancer. The role is one of palliation for advanced disease. Those with better performance status have better survival benefit. Patients with stage I have potential for long survival. Patients with metastatic disease and poor performance status would not benefit from the treatment.

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Citations should be made in the following way:
K. Moghissi, K. Dixon, A. C. Thorpe, C. Percy (Goole, Leeds, United Kingdom). Regional laser centre experience in bronchoscopic photodynamic therapy (PDT) in inoperable bronchopulmonary cancer. Eur Respir J 2002; 20: Suppl. 38, 3720

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