Source: Annual Congress 2002 - Interstitial lung disease
Disease area: Interstitial lung diseases

Abstract

Nonspecific Interstitial Pneumonia (NSIP) is a subtype of idiopathic interstitial pneumonias (provisional), while encompasses heterogeneous status. In addition to spatial diversity (pathological and radiological findings), variety in the time course makes itself more complex. To clarify the characteristics and time course of NSIP, we retrospectively analyzed the time course of clinical data including HRCT findings of 16 patients with NSIP (5 cellular NSIP and 11 fibrosing NSIP ; surgical lung biopsy). HRCT findings were semiquantified by our method previously described (Thorax, 2000, 55: 854). Serum LDH level in fibrosing NSIP was significantly higher than cellular NSIP. CT grade of ground glass opacity in cellular NSIP was significantly larger than fibrosing NSIP. 13 patients were treated with glucocorticoid and/or immunosuppressive agent, and all patients responded, though two patients fluctuated for over 9 years and died (initial diagnosis BOOP or CEP, and finally by surgical biopsy, and autopsy were done). In 16 patients, CT grade of both ground glass opacity and consolidation significantly improved after the therapy (p < 0.05). Honeycombing appeared during the long follow-up period. We conclude patients with NSIP show variable manifestations. They may significantly recover after treatment. However many patients have some persistent fibrosing abnormalities on HRCT including bronchiectasis and end stage honeycomb lung.

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Y. Inoue, M. Akira, T. Arai, S. Yamamoto, A. Yoshida, K. Inoue, Y. Kashiwa, E. Fujita, S. Yotsumoto, S. Minamoto, K. Suzuki, N. Okada, K. Kimura, M. Sakatani (Sakai/Nagasone, Japan). Clinical course of nonspecific interstitial pneumonia: sequential HRCT findings. Eur Respir J 2002; 20: Suppl. 38, 3679

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