Transforming growth factor-α (TGF-α)-induced interleukin-8 (IL-8) release in human bronchial epithelial cells in vitro: role of mitogen-activated protein kinases (MAPK)

F. Luppi, J. Aarbiou, W. I. de Boer, K. F. Rabe, P. S. Hiemstra (Leiden, Rotterdam, The Netherlands)

Source: Annual Congress 2002 - Airway epithelial cell activation, proliferation and differentiation
Session: Airway epithelial cell activation, proliferation and differentiation
Session type: Poster Discussion
Number: 3548
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Luppi, J. Aarbiou, W. I. de Boer, K. F. Rabe, P. S. Hiemstra (Leiden, Rotterdam, The Netherlands). Transforming growth factor-α (TGF-α)-induced interleukin-8 (IL-8) release in human bronchial epithelial cells in vitro: role of mitogen-activated protein kinases (MAPK). Eur Respir J 2002; 20: Suppl. 38, 3548

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2, via activation of p38 mitogen-activated protein kinase
Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms
Year: 2005


Thrombin activates mitogen activated protein (MAP) kinase and activated protein-1 (AP-1) to induce interleukin-8 (IL-8) release from airway epithelial cells
Source: Annual Congress 2003 - Mechanisms of lung injury: from bench to bedside
Year: 2003


Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence or presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005

Inhibitory effects of the IL-6 receptor superantagonist SANT7 on MAP kinase phosphorylation and cell proliferation induced by IL-6 and TGF-beta1 in human lung fibroblasts
Source: Annual Congress 2008 - Clinical aspects of interstitial lung disease
Year: 2008

Intra-hemodialytic hypotension induces tumour necrosis factor-a (TNF-a) production to activate neutrophil mitogen-activated protein kinase (MAPK) in critical Ill patients
Source: Eur Respir J 2003; 22: Suppl. 45, 588s
Year: 2003

Thrombin induces stomatin-like protein 2 (STOML2) expression and IL-8/CXCL8 release by ROCK, JNK, and PEA3 pathways in human lung epithelial cells
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020

Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages
Source: Eur Respir J 2004; 23: 805-812
Year: 2004



Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure
Source: Eur Respir J 2005; 25: 797-803
Year: 2005



Bone morphogenetic proteins (BMPs) inhibit hypoxia stimulated human pulmonary artery fibroblast (PAF) proliferation via inhibition of p38 MAP kinase and HIF-1α
Source: Annual Congress 2004 - Pathophysiology of pulmonary hypertension
Year: 2004


Mitogen-activated protein-kinase modulation of NF-kappaB-induced GM-CSF release from human alveolar macrophages
Source: Eur Respir J 2003; 22: Suppl. 45, 392s
Year: 2003

Bradykinin phosphorylates ERK1/2 through epidermal growth factor receptor transactivation in human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 341s
Year: 2005

Molecular mechanisms of the synergy between cysteinyl-leukotrienes and receptor tyrosine kinase growth factors on human bronchial fibroblast proliferation
Source: Eur Respir Rev 2006; 15: 172-174
Year: 2006



Molecular mechanisms of the synergy between cysteinyl-leukotrienes and receptor tyrosine kinase growth factors on human bronchial fibroblast proliferation
Source: Eur Respir J 2006; 28: Suppl. 50, 339s
Year: 2006

Effects of endothelin-1 on MAPK activation, IL-6 production and cell proliferation in normal human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

Dimethylfumarate reduces growth factor- and cytokine-induced IL-6 release from human lung fibroblasts: role of (NF)-κB
Source: Annual Congress 2008 - Airway cell biology and immunology
Year: 2008

Jun kinase regulates the expression of TGF-beta induced connective tissue growth factor in human lung fibroblast
Source: Annual Congress 2004 - Inflammation and remodelling in human lungs
Year: 2004


Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression
Source: Eur Respir J 2003; 22: Suppl. 45, 10s
Year: 2003

Involvement of protein kinase A (PKA) in the IL-1β induced MCP-1 production in human airway smooth muscle cells
Source: Eur Respir J 2001; 18: Suppl. 33, 353s
Year: 2001

YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK, ERK1/2) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012