Bcl-2 antagonist ABT-737 attenuates corticosteroid-insensitive neutrophilic airway inflammation

Bao-ping Tian (Hangzhou , China), Bao-ping Tian, Li-xia Xia, Fen Lan, Ping-li Wang, Zheng-qiang Bao, Zhi-Hua Chen, Song-min Ying, Hua-Hao Shen

Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Session: Therapeutic approaches in inflammatory lung disease
Session type: Thematic Poster Session
Number: 3906
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Bao-ping Tian (Hangzhou , China), Bao-ping Tian, Li-xia Xia, Fen Lan, Ping-li Wang, Zheng-qiang Bao, Zhi-Hua Chen, Song-min Ying, Hua-Hao Shen. Bcl-2 antagonist ABT-737 attenuates corticosteroid-insensitive neutrophilic airway inflammation. Eur Respir J 2015; 46: Suppl. 59, 3906

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
LATE-BREAKING ABSTRACT: Induction of granulocyte apoptosis by Bcl-2 inhibitors reduces steroid-insensitive airway inflammation
Source: International Congress 2016 – Novel mechanisms and therapeutic targets in acute and chronic inflammatory disease
Year: 2016


CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016

Andrographolide restores steroid sensitivity to block LPS/IFN-γ-induced IL-27 and airway hyperresponsiveness in mice
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015


Effect of the combination of doxofylline and montelukast on LPS-induced leukocyte migration to the lung
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

The immunomodulatory activity of protein S protects against allergic airway inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015

Osteopontin binds and modulate the antibacterial action of eosinophil-recruiting chemokines during allergic inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015

Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

BmTI-A: A serine protease inhibitor attenuates hyperresponsiveness in an experimental model of chronic allergic inflammation in Balb/c mice
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014

cPLA2alpha inhibitor ASB14780 suppresses airway MMP-9 production and improves respiratory function in cigarette-smoke induced model
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014


A novel inhaled PI3Kδ inhibitor, LAS194223 reduces allergen-induced airway inflammation in rat
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014

Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Low level laser in monotherapy or in combination with leukotriene receptor antagonists in the treatment of allergic lung inflammation
Source: International Congress 2015 – Chronic airway disorders: miscellaneous aspects
Year: 2015

Effect of retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness
Source: International Congress 2015 – Immune aspects of asthma and other airway diseases
Year: 2015

PI3Kδ inhibition confer efficacy in experimental models of allergic airway inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015


ARRY-502, a potent, selective, oral CRTh2 antagonist reduces Th2 mediators in patients with mild to moderate Th2-driven asthma
Source: International Congress 2014 – Novel approaches to human studies in allergy and asthma
Year: 2014


Repeated lipopolysaccharide stimulation causes corticosteroid insensitive inflammation in lung via phosphoinositide-3-kinase δ signaling
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Galectin-9 attenuates elastase-induced emphysema by reducing neutrophil chemotaxis in mice
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016

Alpha-7 nicotinic receptor stimulation reduces airway inflammation in a murine model of asthma
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016