No shunting towards LTB4 when blocking LTC4s in vitro

Pernilla Glader (Mölndal, Sweden), Pernilla Glader, Swedin Linda, Wissing Britt-Marie, Göransson Melker, Davis Andy

Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Session: Therapeutic approaches in inflammatory lung disease
Session type: Thematic Poster Session
Number: 3892
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Pernilla Glader (Mölndal, Sweden), Pernilla Glader, Swedin Linda, Wissing Britt-Marie, Göransson Melker, Davis Andy. No shunting towards LTB4 when blocking LTC4s in vitro. Eur Respir J 2015; 46: Suppl. 59, 3892

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL5 and IL13 modulate trans-compartmental activation and migration of eosinophils
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015

Importance of levels production of Il-4 in the pathogenesis and formation of the phenotype of asthma
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015


shRNA suppresses of IL-13 production in vitro
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013

LATE-BREAKING ABSTRACT: Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Source: International Congress 2015 – Hot topics on airway diseases: new horizons in treatment
Year: 2015


Dual role of M2 macrophages in asthma
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015

Blood cytotoxic/pro-inflammatory mediators in severe asthma
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

Structural alterations and endothelial activation in pulmonary and bronchial vessels of asthmatics
Source: International Congress 2015 – Pulmonary hypertension in lung disease
Year: 2015

The polyamine spermine inhibits mitochondrial permeability transition (mPT) and apoptosis in human eosinophils
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Aquaporin-3 potentiates murine asthma through mediating T-cell trafficking and chemokine production
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016


Eosinophilic airway inflammation is associated with increased TLR2 and TLR4 expression in adult asthmatics
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014


Therapeutic blockade of IL-4 and 13 signaling with dupilumab (SAR231893/REGN668) inhibits key biomarkers in asthma
Source: Annual Congress 2013 –Treatment of asthma
Year: 2013

Impaired synthesis and transport of immunoglobulin A in severe asthma: Role of IL-13
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015


Immune modulation of the T-cell response in asthma through Wnt10b
Source: International Congress 2014 – Exploring molecular mechanisms of allergy and asthma in animal models
Year: 2014

Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


Direct relationship between inhibition of leukotriene release in lung and free plasma concentration of a LTC4 synthase inhibitor in a rat model
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015

Expression of CysLT2 receptors in asthmatic lung, and the roles in bronchoconstriction
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Characterization QAW039 and QAV680, two novel, potent and selective CRTh2 antagonists
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014


Elevated IL-10 level but not cysteinyl leukotrienes (CysLT) release from leukocytes in vitro correlates with good response to treatment with montelukast in asthmatic patients
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma (AIA)
Source: Annual Congress 2013 –Genetics and mechanisms of, and tests for, allergy
Year: 2013

Expression of CX3CL1 and CX3CR1 in human asthmatic lung in relation to cell survival
Source: International Congress 2014 – New mechanisms in the pathogenesis of asthma and other lung diseases
Year: 2014