Source: International Congress 2015 – Acute and chronic lung diseases: good clinical practice

Abstract

Background:Environmental factors have been considered as triggers to the onset of sarcoidosis in genetically susceptible. We aimed to investigate whether changed environmental factors affected presentation and the course of sarcoidosis by overtime. Methods: We analysed 275 consecutive patients with sarcoidosis. According to the diagnosis date, 157 patients were in the period 1966-1990 (the baseline climate) and the rest (118 patients) were in the period 1991-2004. Statistics: Roger's test for cyclic variation was used to determine the significance. Results: Subacute course was more common in the baseline climate group than the period 1991-2004, as shown

Table 1. features

	Subjects in the years 1966-1990 (baseline climate)	Subjects in the years 1991-2004	P value
Male	42	43	ns
Skin lesions	42 (26.8%)	28 (23.7%)	ns
Respiratory symptoms	76 (48.4%)	77 (65.3%)	p= 0.0027
Erythema nodosum	52 (33.1%)	28 (23.7%)	ns
Neurologic symptoms	4 (2.5%)	4 (3.4%)	ns
Arthralgia/artritis	39 (24.8%)	33 (27.9%)	ns
Ocular involvement	13 (8.3%)	16 (13.6%)	ns
Hepatomegaly	16 (10.2%)	18 (15.3%)	ns
Parotis inv.	13 (8.3%)	5 (4.2%)	ns

 

and

Table 2. features.

Subacute disease	78 (49.7%)	32 (27.1%)	p= 0.00008
Chronic disease	79 (50.3%)	86 (72.9%)	p= 0.00008
Stage 1 disease by chest X-ray	44.4%	44.5%	ns
More than 3 organs involvement	11 (7%)	10 (8.5%)	ns

 

By contrast, chronic course, progressive disease, and respiratory symptoms were more presented in the period 1991-2004. Seasonality of both baseline climate group and the period 1991-2004 peaked in April (spring). Conclusions: changes on the phenotype and worsening of the course in sarcoidosis led us to consider interactions between sarcoidosis and environmental factors.


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Citations should be made in the following way:
Metin Basaranoglu (Istanbul, Turkey), Sevtap Sipahi, Metin Basaranoglu, Mert Bal, Tuncer Karayel. Sarcoidosis: Changed phenotype and worsening of the course by overtime. Eur Respir J 2015; 46: Suppl. 59, 3692

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