Source: International Congress 2015 – Acute and chronic lung diseases: good clinical practice
Disease area: Respiratory infections, Thoracic oncology

Abstract

Introduction: Granulomatous lymphadenitis is a chronic inflammatory condition that can be associated with lymphoproliferative, infectious and autoimmune diseases. An accurate diagnosis is highly desirable in order to define the precise treatmentObjectives: The achievement of an etiology can be highly unpredictable. We performed a retrospective analysis in order to determine in whom an accurate diagnosis was achieved, enabling a correct focused therapy.Methods: Retrospective analysis of medical records of 139 patients with granulomatous lymphadenitis. 65% males, mean age of 48 years, diagnosed in a Portuguese Cancer Center during a period of six and a half years.Results: 103 patients had peripheral lymphadenopathy and 36 had mediastinal or hylar lymphadenopathy. 30 patients had a past cancer history and 7 patients a past history of lung tuberculosis or tuberculous lymphadenitis. Pathological diagnosis was made by fine needle aspiration cytology in 65%, transbronchial needle aspiration in 24%, surgical biopsy in 9% and mediastinoscopy in 1%. Etiology was achieved in 70 patients (50%). The most frequently identified pathologies were tuberculous lymphadenitis in 33 patients, sarcoidosis in 24 patients, non-hodgkin lymphoma in 3 patients and toxoplasmosis in 3 patients. In 11 patients with mediastinal or hilar lymphadenopathy and in 58 with peripheral lymphadenopathy the etiologic diagnosis was not determined.Conclusion: A wide variety of clinical diagnoses particular neoplastic and benign diseases was found, some of which are rare. Although in half of the patients it was not possible define an etiology, oncologic disease was excluded and patients were referred to their assistant physician for follow-up.


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Madalena Sofia Antunes Reis (Paúl-Covilhã, Portugal), Madalena Reis, Paulo Mota, Jorge Dionísio, José Duro da Costa. Granulomatous lymphadenitis: Experience of a portuguese oncologic institute. Eur Respir J 2015; 46: Suppl. 59, 3683

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