Source: International Congress 2015 – Best abstracts in chronic care
Disease area: Airway diseases

Abstract

Backgroundrecently new tools have been developed to improve airway clearence in patients with Chronic Obstructive Pulmonary Disease (COPD)Aims and objectivesThe study aims to evaluate two new tools : Oscillatory Positive Expiration pressure (O-PEP) and to Temporary Positive Expiration Pressure (T-PEP) . T-PEP gives positive pressure only in the first part of the expiration phase. O-PEP combines PEP therapy with airway vibrations . Both therapies apply a low pressure of 1 H₂O creating oscillations that promote airway secretions' clearence.We have evaluated their role to reduce exacerbations and to improve pulmonary function tests and patients' dyspnea ( MMRC scale ) and quality of life scales ( CAT,BCSS) in severe COPD.MethodsWe selected 99 severe COPD patients for a randomized, open label 36 weeks study. 34 patients received T-PEP + standard medical therapy (STM) , 33 O-PEP + STM and 32 STM.The primary outcome was the number of exacerbations after 6 months.The secondary outcome changes in pulmonary function tests and dyspnea and quality of life scalesResultsRegarding the primary outcome , only TPEP statistically reduced the exacerbations after 6 months (p<0.04). The two tools significantly improved pulmonary function tests and dyspnea and quality of life scales compared to the control group. No significant difference between two techniques to improve the lung function tests and dyspnea or quality of life scales.ConclusionT-PEP and O-PEP improve equally pulmonary function tests, dyspnea and quality of life scales, but only T-PEP reduces COPD exacerbations.


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Antonello Nicolini (Sestri Levante, Italy), Antonello Nicolini, Valentina Mascardi, Bruna Grecchi. Comparison of effectiveness of two positive expiratory devices in severe COPD patients: Temporary positive expiratory pressure (TPEP) versus oscillatory positive expiratory pressure ( OPEP ). Eur Respir J 2015; 46: Suppl. 59, 3065

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