Source: International Congress 2015 – Best abstracts in chronic care
Disease area: Airway diseases

Abstract

BackgroundThe aim of this study is verify if adding temporary positive airway pressure (T-PEP) treatment to the best bronchodilator therapy both at hospital and at home administering could reduce disease exacerbations and improve lung function in patients with severe COPDMethods and Methods120 patients with severe COPD ( FEV1 < 50% ) were randomized in three groups: a group treated with T-PEP at home ,a group with T-PEP at hospital and a group with medical therapy only .Number of exacerbations after 1 ,3, 6 months was the primary outcome. Secondary outcomes were changes in respiratory function parameters ( FVC,FEV1,TLC,RV),arterial blood gases analysis, dyspnea and quality of life scales Modified Medical Research Council ,Breathlessness, Cough and Sputum scale and COPD Assessment Test .The daily use of the T-PEP was registered as well as its acceptance using a Likert scaleResults99 patients completed the study . Both the groups who used T-PEP showed a statistical reduction in exacerbations after 3 and 6 months ( p<0.01) .Some respiratory functional parameters improved in the two groups treated with T-PEP ( FVC,FEV1,RV)) (p<0.02) as well as dyspnea and quality of life scales (MMRC,BCSS,CAT) (p<0.04).The daily using was similar in the two T-PEP groups. Patients treated at home showed a greater acceptance than those treated at hospital ( Likert scale 4.2 vs 5.9 ).ConclusionsTreatment with T-PEP demonstrated efficacy to reduce exacerbations in patients with severe COPD .T-PEP improves functional respiratory parameters and dyspnea and quality of life scales. No adherence difference in hospital and home treatment was found.


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Valentina Mascardi (Sestri Levante, Italy), Valentina Mascardi, Ines Maria Grazia Piroddi, Bruna Grecchi, Antonello Nicolini. Effectiveness of temporary positive expiratory pressure (T-PEP) at home and at hospital in patients with severe COPD. Eur Respir J 2015; 46: Suppl. 59, 3058

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