Source: International Congress 2015 – New data on established treatments for asthma, COPD and bronchiectasis
Disease area: Airway diseases

Abstract

Introduction: Asthma affects around 8% of pregnant women.Studies show that women experience changes in prescriptions for asthma medications during pregnancy, maybe because of concerns about their potential adverse effects on the fetus.Aim: To describe asthma medications before and during pregnancy in France.Methods: Women from EFEMERIS, a French database including prescribed and dispensed reimbursed drugs during pregnancy and pregnancy outcomes, who delivered between July 1, 2005 and December 31, 2012 were included. Women with at least 2 dispensations for any asthma medication (ATC code R03) from the 30 days prior to conception through their date of delivery were considered to be asthmatic.Results: 2,977 women over 69,205 (4%) were identified as asthmatic. Almost 62% of asthmatic women received at least one prescription of short-acting b2-agonist (SABA); 63% at least one inhaled corticosteroid (IC), 42% a fixed-combination of IC and long-acting b2-agonist (LABA) and 8% a LABA. Both increased use of SABA and IC and decreased use of fixed-combination were observed through pregnancy compared to pre-pregnancy period. Women received 3.5±2.7 asthma medications during the period. Asthmatic women were older, were more frequently smokers and suffered more from diabetes compared to non-asthmatic women (p<.05). The pregnancy duration, birth weight, rate of neonatal pathology and congenital anomaly were not different between the two groups (p>.05).Conclusion: Exposition to antiasthmatic drugs varies during pregnancy, with short-acting b2-agonist and inhaled corticosteroid being the more prescribed. Our study shows no difference concerning child health between asthmatic and non-asthmatic women.


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Alain Didier (Toulouse, France), Alain Didier, Anna-belle Beau, Isabelle Lacroix, Caroline Hurault-Delarue, Jean-louis Montastruc, Christine Damase-Michel. Asthma medication during pregnancy: A cohort study in EFEMERIS database. Eur Respir J 2015; 46: Suppl. 59, 2951

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