Source: Annual Congress 2002 - Acute exacerbations of COPD: aetiology and therapy
Disease area: Airway diseases, Respiratory infections

Abstract

Background.
Number of COPD cases has been progressively increased in Ukraine. Treatment of acute exacerbation of COPD is not always successful because of inadequate antibiotic therapy.
Aim.
To reveal most frequent infecting agents and their susceptibility to the different types of penicillins in patients with COPD.
Study population and methods.
Medical documentation of 48 patients (38 men, mean age 52,3±]4,7 years) with acute exacerbation of COPD (type I, Anthonisen et al., 1987) was studied. Data of bacteriological analysis of sputum and susceptibility of isolated agents to penicillin, ampicillin, oxacillin and amoxicillin/clavulone acid were evaluated.
Results.
There were 21 (43.8%) patients with Haemophilus influencae/parainfluencae, 12 (25%) with Klebsiella Pneumoniae, 6 (12.5%) with Staphylococcus aureus, 3 (6.8%) with Pseudomonas fluorescens, 3 (6.8%) with Pseudomonas putida, 3 (6.8%) with Serratia marcescens, 3 (6.8%) with Serratia liquefaciens, 2 (4.1%) with Streptococcus agalactiae, 2 (4.1%) with Acinetobacter baumanii in samples of sputum. In 15 (31.3%) cases there was mixt infection. 3 patients (6.8%) had no any bacterial agents isolated in their sputum.
Only 10% of agents were susceptible to penicillin, 35% – to ampicillin, 15% - to oxacillin. However 70% of microorganisms were susceptible to amoxicillin combined with clavulone acid.
Conclusion.
This study has shown that most frequent infecting agents caused acute exacerbation of COPD were Gram-negative microorganisms (Haemophilus parainfluencae and influencae, Klebsiella Pneumoniae) and Staphylococcus aureus. According to antibiogram the prescription of amoxicillin combined with clavulone acid is most expedient in this case.

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Citations should be made in the following way:
K. E. Bogatska, K. Y. Gashynova (Dniepropetrovsk, Ukraine). Most frequent infecting agents caused acute exacerbation of COPD and their suspectability to the different types of penicillins. Eur Respir J 2002; 20: Suppl. 38, 3375

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