Source: Annual Congress 2002 - Acute exacerbations of COPD: aetiology and therapy
Disease area: Airway diseases

Abstract

We are prospectively monitoring all visits in CB oupatients (no asthma or bronchiectasis) referring to our Division, pertaining to a local population of 50.000 inhabitants. Patients classification: degree of airways obstruction (AO), years of productive cough (CS), smoking habit (SH), Anthonisen AECB severity (se, mo, mi). Patients data during year 2000: males 69.3%, age 66±]19 yrs, visits 1.4±]0.6, CS 12.5±]12.1 yrs, AECBse 33.6%, AECBmo 41.6%, AECBmi 24.8%. Statistical analysis results : a) AO degree (mild 17.8%, moderate 56.8%, severe 25.4%) is influenced by years of SH (p= 0.0025) and by years of CS (p= 0.0027); b) maximum likelihood variance analysis applied to the logistic regression model shows no significant risk factor for AECB severity, while the risk factors for AECB frequency are listed in the table. Question: is the smoking habit an independent risk factor for the severity and the frequency of AECB?

RISK FACTORS	ODDS RATIO	p-value
(1) never_SH vs former_SH	0.59 (0.37-0.95)	0.0315
never_SH vs current_SH	0.94 (0.57-1.57)	0.8242 n.s.
former:SH vs current_SH	1.60 (0.98-2.60)	0.0597
(2) mild_AO vs moderate_AO	1.65 (0.90-3.04)	0.1059 n.s.
mild_AO vs severe_AO	3.05 (1.59-5.86)	0.0008
moderate_AO vs severe_AO	1.85 (1.20-2.85)	0.0056
(3) zero_CS vs [lte] 10 yrs_CS	2.06 (1.08-3.96)	0.0292
zero_CS vs > 10 yrs_CS	2.58 (1.33-5.01)	0.0050
[lte]10 yrs_CS vs >10 yrs_CS	1.25 (0.82-1.92)	0.3025 n.s.

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Citations should be made in the following way:
S. Damato, T. Camnasio, V. Frigo, C. Rampoldi, F. Rodi, S. Vernocchi (Seregno, Italy). Risk factors associated with observed severity and frequency of 137 first exacerbations (AECB) in 618 consecutive chronic bronchitis (CB) outpatients. Eur Respir J 2002; 20: Suppl. 38, 3368

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