IgG immunoglobulin levels and the frequency of respiratory infections in patients with chronic obstructive pulmonary disease (COPD)
E. Tsaroucha, G. Pavlakou, D. Antoniou, E. Tsigou, N. Tzogas, H. Ablianitis, E. Anastasakou, O. Anagnostopoulou (Athens, Greece)
Source: Annual Congress 2002 - Acute exacerbations of COPD: aetiology and therapy
Session: Acute exacerbations of COPD: aetiology and therapy
Session type: Thematic Poster Session
Number: 3366
Disease area: Airway diseases
Abstract We compared the total IgG values in patients with COPD and healthy individuals and correlated these values with smoking habit and the frequency of respiratory infections. 80 patients aged x ±]SD 64 ±]6 and 150 healthy individuals aged 62 ±]7 (p >0.10) completed a questionaire, were submitted to lung function tests (spirometry) and total serum IgG levels were measured. 32 patients (Group A) didn't receive systemic steroid treatment and 48 patients (Group B) were treated with inhaled beclomethasone 1000-2000 μg/daily or oral treatment with 5 mgr prednisolone daily. Results : The total IgG values were significantly lower in the group A patients x ±]SD 920 ±]80 μg/dl in comparison to the control group x ±]SD 1210 ±]180 (p <0.005). The total IgG was significantly lower in group B x ±]SD 740 ±]60 μg/dl (p <0.05) in comparison to group A. No differences were observed in the total IgG values between smokers and non smokers both in the healthy individuals and the COPD patients. In the group B, the total IgG was significantly lower in the smokers than the non-smokers. Respiratory infections were frequent in the patients of group A in comparison to the controls (p <0.05) and more frequent in the patients receiving steroids compared to the control group (p <0.01). Conclusion : Low total IgG values contribute to increased respiratory infections in COPD patients which is further enhanced by smoking. Steroids may play a role in the decreased IgG values in these patients.
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E. Tsaroucha, G. Pavlakou, D. Antoniou, E. Tsigou, N. Tzogas, H. Ablianitis, E. Anastasakou, O. Anagnostopoulou (Athens, Greece). IgG immunoglobulin levels and the frequency of respiratory infections in patients with chronic obstructive pulmonary disease (COPD). Eur Respir J 2002; 20: Suppl. 38, 3366
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