Source: Annual Congress 2002 - Acute exacerbations of COPD: aetiology and therapy
Disease area: Airway diseases, Respiratory infections

Abstract

27 patients were inspected by means of spirography, cytology of induced sputum [IS], quantitative bacteriological sputum research, definition of Mycoplasma. pneumoniae and Chlamidia pneumoniae antigens in the sputum by PCR method and IgG, IgM levels by immuno-assay method. Infectional etiology of exacerbation was not proved at 40% that was not except the role of viruses, which was not researched in this work. Infectional character of exacerbation was detected at 60%. Matching IS in infectional exacerbation and noninfectional exacerbation patients group we obtained statistically certain differences on cytosis (P<0,001), where as uncertain differences were revealed between quantity of separate cells kinds. We used Spearman analysis for definition of intercoupling FEV1 and COB exacerbation etiology. There was not correlation (P>0,05) at noninfectional exacerbation etiology. The correlation between FEV1 and absolute quantity of lymphocytes in IS (r=0,74, P<0,05) was revealed at bacterial nature of exacerbation. The straight line correlation relation between FEV1 and absolute lymphocyte quantity in IS (r=0,9, P<0,05), and return correlation relation between FEV1 and absolute neutrophils quantity in IS (r=-0,9, P<0,05) were detected at exacerbation caused by endocellular micro-organisms. The correlation connection between exacerbation etiology and ventilation disturbances degree is established, that is likely to be caused by inflammation features.

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E. B. Bukreeva, S. V. Nesterovich, E. A. Dementyeva, T. G. Melnik, L. V. Gudkova, E. A. Gereng, I. I. Ivanchuk (Tomsk, Russia). Induced sputum cytology at different etiology of exacerbation of chronic obstructive bronchitis. Eur Respir J 2002; 20: Suppl. 38, 3365

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