Source: Annual Congress 2002 - Acute exacerbations of COPD: aetiology and therapy
Disease area: Airway diseases

Abstract

CCSP (Clara cell secretory protein) is an important constitutive protein, which modulates the lung inflammatory responses. Recruitment of neutrophils and macrophages in lung plays an important role in the pulmonary infection and also in the pathogenesis of COPD. Recent studies showed that CCSP inhibits the chemotaxis of macrophages and neutrophils and then suppress the lung inflammation. In this study, we determined the CCSP level (Western blot) and its mRNA expression (RT-PCR), neutrophils elastase (NE)(Meosuc-ala-ala-val-pro-NA method), MIP(marophage infammation protein)-1αand MIP-2 (ELISA) in induced sputum of COPD patients with acute bacterial exacerbation (12 cases) and normal controls (10 cases). The concentration of CCSP and its mRNA expression decreased in COPD patients during acute bacterial exacerbation (p<0.001) and increased after the resolution of infection (p<0.001), but still lower than normal controls (p<0.05). MIP-1α, MIP-2 and NE increased during lung infection but decreased after lung infection (p<0.001). The CCSP and its mRNA expression both significantly negative correlated with the number of neutrophils and macrophages, MIP-1α, MIP-2 and NE. The present results suggested that decreased CCSP may increase neutrophils and macrophages recruitment in the lung, which help the resolution of infection. More neutrophils and macrophages also induced lung tissue destroying which lead to further aggravate of COPD course.

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Citations should be made in the following way:
L. Feng Ming, W. ZengLi (Chengdu, China). Clara cell secretory protein and its mRNA expression in induced sputum of acute bacterial exacerbations of COPD. Eur Respir J 2002; 20: Suppl. 38, 3364

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