HDM-challenged mice exhibit impaired interferon response to TLR3 ligand in a murine model of viral asthma exacerbation

Hamid Akbarshahi (Lund, Sweden), Hamid Akbarshahi, Mandy Menzel, Lena Uller

Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Session: Animal studies of asthma and other inflammatory conditions
Session type: Poster Discussion
Number: 1893
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Hamid Akbarshahi (Lund, Sweden), Hamid Akbarshahi, Mandy Menzel, Lena Uller. HDM-challenged mice exhibit impaired interferon response to TLR3 ligand in a murine model of viral asthma exacerbation. Eur Respir J 2015; 46: Suppl. 59, 1893

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL-37 requires IL18Rα and SIGIRR to diminish experimental allergic airway inflammation in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Interleukin-33 and Th2 cytokines correlate in acute asthma
Source: International Congress 2016 – Clinical and molecular studies in asthma
Year: 2016

Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


TLR-3 triggered exacerbation of experimental asthma depends on IL-17 producing NK cells
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

Influenza induced exacerbation is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice
Source: International Congress 2016 – Immune responses in the lung
Year: 2016


Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

TLR 7/8 agonist resiquimod alleviates murine allergic asthma through IL-27 production and up regulation of B7-H1 on antigen presenting cells
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Autoimmune induction of a COPD-like inflammatory phenotype in mice
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Rapamycin protects OVA induced asthma in mice through regulating autophagy
Source: International Congress 2015 – Exploring mechanisms in obstructive airway diseases
Year: 2015

Preventative administration of IL-27 improves airway inflammation of ovalbumin –induced asthma mice model via both STAT1 and GADD45γ/p38MAPK pathways
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016


IL33 and TSLP involvements in influenza-induced exacerbation in a murine model of chronic asthma
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

Nociceptin modulates the inflammatory immune microenvironment in a conventional murine model of asthma
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015


Farm dust decreases Th2 driven allergic airway inflammation in mice: A role for airway TLR2 and TLR4?
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


TLR7 gene deficiency and early-life pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice
Source: Annual Congress 2013 –Viral infections: what is new?
Year: 2013


Targeting PI3Kd attenuates influenza virus-induced inflammation in a murine model of asthma exacerbation
Source: International Congress 2017 – Infection and exacerbation science
Year: 2017

Transgenic mice overexpressing IL-18 display increased IL-13 in the airways but no changes of the airway hyperresponsiveness in a murine model of late-phase asthma: evidence for a dual role of IL-18 on mucosal Th1/Th2 responses
Source: Eur Respir J 2002; 20: Suppl. 38, 1s
Year: 2002

Aerobic training reverses the inhibition in the expression of glucocorticoid receptors and decreases the Th2 allergic inflammation in asthma model
Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Year: 2013


Micro-RNA-125a/b target A20 and MAVS to promote inflammatory and impair antiviral responses in chronic obstructive pulmonary disease
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Rhinovirus (RV)-induction of IL-15 in macrophages is dependent on type I IFNs, is deficient in asthma and related to exacerbation severity
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010

The role of IL-17 producing NK cells and other innate immune cells in poly(I:C) triggered exacerbation of experimental asthma
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016