IFNγ influences bronchial epithelial anti-viral immune responses via inducible epigenetic control of histone methylation of the RIG-I promoter

Cosma Mirella Spalluto (Southampton, United Kingdom), C. Mirella Spalluto, Akul Singhania, Christopher H. Woelk, Tilman Sanchez-Elsner, Karl J. Staples, Tom M.A. Wilkinson

Source: International Congress 2015 – The multiple faces of host defense
Session: The multiple faces of host defense
Session type: Oral Presentation
Number: 1782
Disease area: Airway diseases, Respiratory infections

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Cosma Mirella Spalluto (Southampton, United Kingdom), C. Mirella Spalluto, Akul Singhania, Christopher H. Woelk, Tilman Sanchez-Elsner, Karl J. Staples, Tom M.A. Wilkinson. IFNγ influences bronchial epithelial anti-viral immune responses via inducible epigenetic control of histone methylation of the RIG-I promoter. Eur Respir J 2015; 46: Suppl. 59, 1782

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Epigenetic control of antiviral and innate immune response following viral infection in a lung epithelial model
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013


Targeted silencing of master transcription factor SPDEF to reduce mucus production in airway diseases by epigenetic editing
Source: International Congress 2015 – Advances in the future treatment of COPD
Year: 2015



The role of suppressor of cytokine signalling 1 (SOCS1) in virus-induced asthma exacerbations
Source: International Congress 2016 – Viral infections in different respiratory conditions: from the bedside to the lab
Year: 2016


Effect of epigenetic probes on IL-1B and polyIC treated normal human epithelial cells
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

Genetic variation in human RHS7 of the TH2 locus control region influences DNA methylation and is associated with IgE
Source: International Congress 2014 – Paediatric asthma: pathogenesis and immunology
Year: 2014

The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy
Source: Eur Respir J 2005; 26: 933-947
Year: 2005



Enhanced inflammatory gene expression in bronchial epithelial cells from asthmatic patients: Attenuation by a Brd4 mimic
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Reduced MicroRNA-19a causes constitutive high expression of PRMT1 and remodeling in asthma
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016


Role of the immunoregulatory microRNA miR-146a in the innate immune response to rhinovirus infection
Source: Annual Congress 2013 –Viral infections: what is new?
Year: 2013


Promoter methylation of Bcl-2 in CSE-induce HUVEC apoptosis
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013

Nociceptin modulates the inflammatory immune microenvironment in a conventional murine model of asthma
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015


Downregulation of IL-27 bronchial epithelial expression by heat-shock protein-60
Source: Annual Congress 2013 –Systemic and airway biomarkers in respiratory diseases
Year: 2013

Oxidative stress alters histone acetylation and deacetylation: potential mechanism in inflammatory gene transcription
Source: Eur Respir J 2001; 18: Suppl. 33, 182s
Year: 2001

Histone demethylation and acetylation are involved in the epigenetic regulation of epithelial-mesenchymal transition (EMT)
Source: Annual Congress 2013 –Novel mechanisms in lung injury
Year: 2013

Egr-1 regulates muc5ac expression through activator protein-1 (AP-1) in chronic airway inflammation diseases
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


Asthma and diabetes: Possible markers of their co-existence. The possible role of transcription factors GATA-3 and T-bet and negative regulator of transcription SOCS1 in the worsening of asthma
Source: International Congress 2015 – Translational research in respiratory care: new findings
Year: 2015

Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016

WNT-4 regulates pro-inflammatory responses driven by epithelial-mesenchymal cross-talk
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells
Source: Annual Congress 2012 - New insights into airway epithelial cell physiology
Year: 2012

Dysregulation of type 2 innate lymphoid cells and Th2 cells impairs pollutant-induced allergic airway responses
Source: International Congress 2016 – Immune responses in the lung
Year: 2016