Source: Annual Congress 2002 - Neonatology and paediatric intensive care
Disease area: Paediatric lung diseases, Respiratory critical care, Sleep and breathing disorders

Abstract

The aim of the present study was to determine the accuracy of arterial to end-tidal CO2 (Pa-etCO2) measurement in newborn infants with respiratory insufficiency.
Methods: recordings of 152 simultaneous arterial and end-tidal CO2 pairs from 38 newborn infants with respiratory disorders. The mean gestational age was 33,5 weeks and mean birth weght was 2150 g. Control group consisted of 18 healthy term neonates.
Results: 15 neonates who required mechanical ventilation Pa-etCO2 exceeded 20 mmHg. All these infants immediately after delivery had respiratory disorders and nasal CPAP was started. But during the next 2-4 hours respiratory insufficiency progressed and required mechanical ventilation. Increasing of Pa-etCO2 was seen 2,2 hours earlier before appearence of clinical symptoms and blood gases changes. In other 23 neonates respiratory disorders required nasal CPAP during 4-26 hours and Pa-etCO2 in these infants was 10-20 mmHg. In control group Pa-etCO2 was 4-8 mmHg.
Conclusion: Pa-etCO2 in neonates with respiratory disorders is an accurate index of ventilation-perfusion mismatch and allows to make an early prediction of necessity of mechanical ventilation.

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Citations should be made in the following way:
M. N. Kosov (St-Petersburg, Russia). Arterial to end-tidal carbon dioxide measurements in neonates with respiratory disorders. Eur Respir J 2002; 20: Suppl. 38, 3300

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