Chymase-positive mast cells represent a major source for IL-17A in airway inflammation

Premkumar Siddhuraj (Lund, Sweden), Premkumar Siddhuraj, Anders Bergqvist, Michiko Mori, Leif Bjermer, Jonas Erjefält

Source: International Congress 2015 – Mucosal immunology: what’s new in 2015
Session: Mucosal immunology: what’s new in 2015
Session type: Poster Discussion
Number: 381
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Premkumar Siddhuraj (Lund, Sweden), Premkumar Siddhuraj, Anders Bergqvist, Michiko Mori, Leif Bjermer, Jonas Erjefält. Chymase-positive mast cells represent a major source for IL-17A in airway inflammation. Eur Respir J 2015; 46: Suppl. 59, 381

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL-8 and TSLP production as markers of bronchial epithelial cell activation in IL-17A mediated airway inflammation in COPD: Role of tiotropium
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

The percentage of neutrophils expressing TLR4 in induced sputum decreases in asthma not eosinophilic
Source: Annual Congress 2013 –Asthma
Year: 2013


Imbalance of pro-inflammatory and anti-inflammatory markers on circulating dendritic cells in COPD
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

The human cathelicidin LL37 and mitochondrial DAMPs induce airway inflammation in epithelial cells and mice
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015


CEACAM6-high airway neutrophils and epithelial cells are a feature of severe asthma
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Relationship between monocyte-derived macrophage phagocytosis and airway inflammation in stable COPD
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013


Modulation of inflammation by benralizumab in eosinophilic airway disease
Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Year: 2016


Peripheral blood Th9 cells and IL-9 level in asthma patients with early and dual asthmatic response
Source: International Congress 2015 – Novel mechanisms and treatments in allergy and asthma
Year: 2015



IL-37 requires IL18Rα and SIGIRR to diminish experimental allergic airway inflammation in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Elevated IL-17A in very severe COPD is localized to mast cells and correlates with lung function decline
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

Association between T-regulatory cells blood content and Th2 cells activity in asthma
Source: Annual Congress 2013 –Asthma: new mechanisms and markers
Year: 2013

IL5 and IL13 modulate trans-compartmental activation and migration of eosinophils
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015

The role of chemokine receptors in the aberrant migration of COPD neutrophils
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Inflammatory cell activation in eosinophilic and non-eosinophilic asthma
Source: Annual Congress 2006 - Immunology of the airways
Year: 2006


Decreased regulation of lung CD8+ T cells by virally-infected macrophages in COPD: Role of PD1/PDL1 axis
Source: International Congress 2015 – Advances from translational research in respiratory infections
Year: 2015

Mapping of eosinophil and basophils in COPD lung tissues
Source: International Congress 2015 – Mucosal immunology: what’s new in 2015
Year: 2015

Dysregulation of type 2 innate lymphoid cells and Th2 cells impairs pollutant-induced allergic airway responses
Source: International Congress 2016 – Immune responses in the lung
Year: 2016

LSC 2014 abstract - A20 levels in dendritic cells control eosinophilic versus neutrophilic lung inflammation in asthma
Source: International Congress 2014 – Exploring molecular mechanisms of allergy and asthma in animal models
Year: 2014


Imbalance of immune response functional phenotype and alveolar macrophages phenotype in COPD
Source: International Congress 2014 – New insights into monocyte and macrophage biology
Year: 2014


Mast cells and eosinophils: the two key effector cells in allergic inflammation
Source: Annual Congress 2010 - Mast cells and eosinophils: the two key effector cells in allergic inflammation
Year: 2010