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Amsterdam 2015
Sunday, 27.09.2015
New data on established treatments for asthma and COPD
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Lung function change and exacerbations in patients with COPD in the WISDOM study
Henrik Watz (Grosshansdorf, Germany), Henrik Watz, Helgo Magnussen, Anne Kirsten, Kay Tetzlaff, Helen Finnigan, Bernd Disse, Eric Bateman
Source:
International Congress 2015 – New data on established treatments for asthma and COPD
Session:
New data on established treatments for asthma and COPD
Session type:
Thematic Poster Session
Number:
1019
Disease area:
Airway diseases
Abstract
Introduction:
The WISDOM study (NCT00975195) showed that in patients with severe to very severe COPD receiving tiotropium + salmeterol, risk of moderate or severe exacerbations was non-inferior in patients discontinuing inhaled corticosteroids (ICS) compared to those continuing ICS. However, patients in the ICS-withdrawal arm had a small reduction in trough FEV₁ (43 mL; p<0.01). We analysed
post hoc
the relationship of the change in FEV₁ in both treatment arms to moderate or severe exacerbations.
Methods:
All patients were categorised into three groups according to the tertiles (33rd and 67th percentiles) of the change from baseline in trough FEV₁ after 1 year of treatment; decrease (<-130 mL), medium change (
³
-130 mL to <20 mL) or increase (
³
20 mL). The change groups were analysed using descriptive statistics.
Results:
The percentage of patients with moderate or severe on-treatment exacerbation was similar between the decrease and increase FEV₁ change groups, and
~
10% higher in the medium change group (Table). These findings were similar in the ICS and ICS-withdrawal arms.
Conclusions:
In the WISDOM study, no apparent relationship was observed between the magnitude of change in FEV₁ and exacerbations over 1 year of treatment in patients with severe to very severe COPD receiving tiotropium + salmeterol, with or without ICS therapy.
Funding: Boehringer Ingelheim.
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Henrik Watz (Grosshansdorf, Germany), Henrik Watz, Helgo Magnussen, Anne Kirsten, Kay Tetzlaff, Helen Finnigan, Bernd Disse, Eric Bateman. Lung function change and exacerbations in patients with COPD in the WISDOM study. Eur Respir J 2015; 46: Suppl. 59, 1019
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