Glycopyrronium (GLY) and tiotropium (TIO) comparison: Lung function, dyspnea and health status in COPD patients in all GOLD groups
Anthony D. D'Urzo (Toronto, Canada), Anthony D’Urzo, Giovanni Bader, Pablo Altman, Pankaj Goyal
Source: International Congress 2015 – New data on established treatments for asthma and COPD
Session: New data on established treatments for asthma and COPD
Session type: Thematic Poster Session
Number: 1010
Disease area: Airway diseases
Abstract Inhaled LAMAs are recommended for COPD patients in all GOLD groups (A,B,C&D)1 . GLY 50µg is effective and well tolerated in moderate-to-severe COPD patients, similar to TIO 18µg, and with faster onset and better bronchodilation in the first 4h after the first dose.The effect of GLY and TIO in patients categorized by GOLD group was analyzed post hoc using data from 4 randomized controlled clinical trials pooled and adjusted using mix-model. GOLD classification was done based on baseline St George's Respiratory Questionnaire (SGRQ) score (cut point=25) and lung function (FEV₁; </> 50% predicted normal) without baseline exacerbation risk. Efficacy of GLY and TIO was analyzed by mean change from baseline at 12 wks for trough FEV1 (tFEV₁), SGRQ score, and TDI score.Of 2599 patients (GLY=1628, TIO=971), 7.6%, 52.6%, 2.8% and 37.0% were classed in GOLD groups A, B, C and D respectively. GLY showed significant improvement in tFEV₁ in patients in all groups after 12 treatment wks compared with baseline; TIO showed significant improvement only in B&D groups. In group A, GLY was significantly better than TIO [least square means difference for tFEV₁ GLY vs TIO: 75 ml (CI: 25, 125; p=0.0036)]. GLY significantly improved dyspnea in patients in all GOLD groups, similar to TIO. GLY and TIO showed similar and significant improvement in SGRQ only in GOLD groups B&D.In conclusion, GLY and TIO significantly improved dyspnea (in all GOLD groups) and health status (GOLD Groups B&D). GLY provided significant improvement in tFEV₁ in patients in all GOLD groups, while TIO showed statistically significant improvement in tFEV₁ only in patients in group B&D.1. GOLD 2015.
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Anthony D. D'Urzo (Toronto, Canada), Anthony D’Urzo, Giovanni Bader, Pablo Altman, Pankaj Goyal. Glycopyrronium (GLY) and tiotropium (TIO) comparison: Lung function, dyspnea and health status in COPD patients in all GOLD groups. Eur Respir J 2015; 46: Suppl. 59, 1010
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