Effects of the new ultra-long-acting β2-AR agonist indacaterol in chronic treatment alone or in combination with the β1-AR blocker metoprolol on cardiac remodelling

Luigino Calzetta (Rome, Italy), Luigino Calzetta, Barbara Rinaldi, Maria Donniacuo, Eugenio Martuscelli, Augusto Orlandi, Maria Gabriella Matera

Source: International Congress 2015 – Safety of and interactions between current treatments for asthma and COPD
Session: Safety of and interactions between current treatments for asthma and COPD
Session type: Thematic Poster Session
Number: 992
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Luigino Calzetta (Rome, Italy), Luigino Calzetta, Barbara Rinaldi, Maria Donniacuo, Eugenio Martuscelli, Augusto Orlandi, Maria Gabriella Matera. Effects of the new ultra-long-acting β2-AR agonist indacaterol in chronic treatment alone or in combination with the β1-AR blocker metoprolol on cardiac remodelling. Eur Respir J 2015; 46: Suppl. 59, 992

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Abediterol has higher bronchodilatory potency and reduced cardiac effects versus other long-acting beta2-agonists in dogs
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014

The inverse agonist propranolol does not confer steroid-sparing activity in persistent asthma
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014


The combination therapy with inhaled tiotropium bromide and indacaterol in COPD improves the peripheral airway function in static and dynamic status
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

Synergistic effects by combination of tiotropium with olodaterol result from cross talk between muscarinic and β2-adrenergic receptors via allosteric modulation
Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action
Year: 2016


Abediterol has higher bronchodilatory potency than other long-acting beta2-receptor agonists in a guinea pig model
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Safety and efficacy of the inhaled pan-selectin antagonist bimosiamose in patients with COPD
Source: Eur Respir J 2007; 30: Suppl. 51, 613s
Year: 2007

Effect of the combination of doxofylline and montelukast on LPS-induced leukocyte migration to the lung
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

Effect of the CYP3A4 inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of AZD5069, an oral CXCR2 antagonist
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014


Individual and differential treatment responses to once-daily long acting bronchodilators, glycopirronium and indacaterol, and combination of both drugs in the patients with moderate or severe COPD
Source: International Congress 2014 – New clinical evidence for asthma and COPD treatments
Year: 2014

Translational study searching for synergy between glycopyrronium and indacaterol
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Effect of omeprazole and AlOH/MgOH on riociguat absorption
Source: Annual Congress 2013 –Pulmonary circulation: clinical diagnosis, imaging, biomarkers and treatment
Year: 2013

Efficacy and safety of abediterol, a long-acting beta2-adrenergic agonist (LABA); three phase II trials in asthma
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014

Pharmacological characterization of the mechanism of action leading to synergism between glycopyrronium bromide and indacaterol fumarate
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Once-daily tiotropium and olodaterol fixed-dose combination via the respimat improves outcomes vs mono-components in COPD in two 1-year studies
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Once-daily QVA149 improves lung function and dyspnoea compared with tiotropium plus formoterol: The QUANTIFY study
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


Safety and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in patients with COPD
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008

Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014