Source: International Congress 2015 – Lung function: exploring the boundaries of the respiratory system
Disease area: Interstitial lung diseases

Abstract

Background: Pulmonary involvement is a prominent feature in systemic sclerosis (SSc) and a significant cause of morbidity and mortality. A restrictive ventilatory defect is typical and static lung volumes are usually reduced in patients with interstitial lung diseases. The possibility of obstruction of small airways in progressive SSc has been suggested by widespread bronchiolectasis and peribronchial fibrosis noted at necropsy.Objective: To study the functional properties of the respiratory system in SSc patients.Materials and Methods: 66 patients (9 M/57 F, mean age 51 ± 12 yrs.) suffering from limited (58%) and diffuse (42%) forms of systemic sclerosis were examined. Spirometry, body plethysmography and gas transfer test were performed.Results: Obstructive disorders were identified in 20 patients (30%), restrictive - in 11 (17%), mixed disorders - in 5 (8%). Lung function was normal in 30 (45%) patients. Diffusion capacity (DLco) was decreased in 54 (82%) SSc patients: 19 (35%) patients had mild (DLco = 60-80% of predicted.), 20 (37%) - a moderate degree (DLco = 40 -60% pred.), 15 (28%) - severe degree (DLco less than 40% predicted). DLco was normal in 12 (18%) patients. Functional markers VC, TLC, DLco were lower in patients with diffuse form than in patients with limited form of systemic sclerosis, but the data were not statistically significant (p> 0.05). The correlation between functional parameters of the respiratory system and duration of the disease in patients with SSc has not been identified.Conclusion: Airflow obstruction and isolated impairment of DLco are more common in patients with SSc. DLco measurement could be a useful diagnostic tool for SSc.


Rating:

Share or cite this content

Citations should be made in the following way:
Malika Mustafina (Moscow, Russian Federation), Malika Mustafina, Alexandr Cherniak, Galina Nekludova, Olga Koneva, Oksana Desinova. Respiratory function in systemic sclerosis patients. Eur Respir J 2015; 46: Suppl. 59, 962

Member's Comments

No comment yet.

Related content which might interest you: An increased respiratory drive accounts for the severity of dyspnea in systemic sclerosis Source: Annual Congress 2013 –Respiratory muscles at rest and during exercise: from physiology to clinical context Year: 2013 Novel lung function tests in patients with interstitial lung disease (ILD) Source: International Congress 2016 – Clinical aspects of ILD Year: 2016 Pulmonary involvement in children with rheumatic diseases Source: International Congress 2016 – Connective tissue disorders Year: 2016 Lung structure and function relation in systemic sclerosis: Application of lung densitometry Source: International Congress 2015 – A more functional view of chest pathology Year: 2015 Scleroderma lung disease: Detection of pulmonary hypertension using pulmonary function tests is problematic in patients with emphysema Source: Annual Congress 2013 –Connective tissue disease and interstitial lung disease Year: 2013 Serum surfactant protein D is a potential biomarker of lung damage in systemic sclerosis Source: International Congress 2016 – Connective tissue disorders Year: 2016 The prognostic factor in patients with myositis-associated interstitial lung disease Source: International Congress 2014 – ILDs: connective tissue disease Year: 2014 Pulmonary involvement in Moldova lupus study Source: Annual Congress 2013 –Diffuse parenchymal lung disease III Year: 2013 Scleroderma lung disease: A scleroderma physiologic index (SPI) derived from lung physiology and oxygen saturation Source: Annual Congress 2013 –Connective tissue disease and interstitial lung disease Year: 2013 The diagnostic of the respiratory pathology in patients with rheumatoid arthritis (RA) Source: International Congress 2016 – The best clinical approach to lung diseases Year: 2016 The role of detection of myositis specific and associated antibodies in Japanese patient with interstitial lung disease Source: International Congress 2014 – ILDs: connective tissue disease Year: 2014 Pulmonary function involvement in scleroderma Source: Annual Congress 2013 –Diffuse parenchymal lung disease II Year: 2013 Usefulness of a myositis antibody immunoblot in diagnosis of connective tissue disease (CTD) related interstitial lung disease (ILD) Source: International Congress 2014 – ILDs 4 Year: 2014 Pulmonary manifestations in rheumatoid arthritis: A hospital based descriptive study Source: International Congress 2014 – ILDs: connective tissue disease Year: 2014 Pulmonary function tests as predictors of mortality in patients with sarcoidosis Source: International Congress 2015 – Sarcoidosis: clinical Year: 2015 Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement Source: International Congress 2014 – ILDs: connective tissue disease Year: 2014 Relevance of the expert ILD clinical-radiological evaluation of referred cases to the MDT Source: International Congress 2016 – Clinical aspects of ILD Year: 2016 Antisynthetase syndrome (AS) in patients with diffuse interstitial lung disease (ILD) Source: International Congress 2015 – Connective tissue disorders Year: 2015 Study of factors affecting mortality in ILD cases over 2 years Source: International Congress 2016 – Clinical aspects of ILD Year: 2016 Are there any clinical differences between SSc-ILD and UCTD suspected of SSc -ILD? Source: International Congress 2015 – Connective tissue disorders Year: 2015