Source: International Congress 2015 – Lung function: exploring the boundaries of the respiratory system
Disease area: Airway diseases, Interstitial lung diseases

Abstract

Background: The test of the diffusing capacity of the lungs for carbon monoxide (DLCO) had rarely been available for use in outpatient settings until 2010.Aim: Our objective was to assess the difference of the reference value of DLCO for Japanese workers between the use of Nishida's regression formula for Japanese subjects and the U.S. Third National Health and Nutrition Examination Survey (NHANES) III.Methods: We conducted a health check between 2012 and 2014. For all 214 workers, the DLCO test was completed with adequate session quality. We selected 194 workers with normal KL-6 levels. The characteristics of the 194 subjects were: mean age (41 yrs), mean body mass index (24.1). The DLCO and DLCO/alveolar volume (VA) values were determined for each gender, using the two regression formulas.Results: The observed mean values for the male and female subjects, respectively were as follows: DLCO 26.8 (standard deviation [SD] 5.0) and 19.4 mL/min/mmHg (SD 2.5). The calculated mean values for %DLCO using Nishida's regression formula were %DLCO 92.2% (SD 14.1) in the males and 85.1% (SD 11.0) in the females. The difference between the mean %DLCO using the two formulas' means was 11.2% (males) and 4.6% (females), and the results of the difference were the same in the non-smokers (n=83). The prediction formula in the males in our study was as follows: DLCO = 1.548 - 0.217*age + 0.201* height (cm) (r² = 0.386). The interpretation of the females' data is difficult because of the small number of females(n=19).Conclusions:The evaluation of DLCO for Japanese using the NHANES III regression formula results in a 10% underestimation.


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Makiko Nakano (Tokyo, Japan), Makiko Nakano, Satoko Iwasawa, Akiyo Tanaka, Miyuki Hirata, Kazuyuki Omae. Assessment of the Japanese reference value of a new portable instrument for the diffusing capacity of the lungs for carbon monoxide. Eur Respir J 2015; 46: Suppl. 59, 952

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