Correlations between fractional exhaled nitric oxide and age and lung function in healthy Thai adults
Wilaiwan Khrisanapant (Khon Kaen, Thailand), Wilaiwan Khrisanapant, Tichanon Promsrisuk, Orapin Pasurivong, Watchara Boonsawat, Boonsong Patjanasoontorn, Burabha Pussadhamma, Paitoon Benjapornlert
Source: International Congress 2015 – Lung function: exploring the boundaries of the respiratory system
Disease area: Airway diseases
Abstract Measurement of fractional exhaled nitric oxide (FeNO) has been used as a marker of airway inflammation. Factors affecting the FeNO levels are inconsistent among different populations and studies. We examined differences in FeNO levels between genders and associations between FeNO levels with age, weight, height and lung function in healthy Thai 20-78 year of age. The FeNO levels and pulmonary function were performed in 127 healthy Thais (49 males, 78 females). All subjects had normal ranges of clinical characteristics and pulmonary function although weight, height and systolic blood pressure in males were higher than in females (p<0.001). A comparison between males and age-matched females (n = 49; 30.4±10.7 yr vs. n = 49, 31.9±9.4 yr) showed significantly higher FeNO levels in males; 13.3±5.3 ppb vs. 9.6±5.4 ppb, p<0.001. Moreover, there were positive correlations between FeNO levels with age (r = 0.375, p<0.001), weight (r = 0.133, p<0.05) and height (r = 0.087, p<0.05) and a negative correlation with FEF25-75% (r = -0.228, p<0.05) but not with FEV1, FVC or PEF. The present study provides FeNO levels in healthy Thai subjects in both genders. We also demonstrate that males have an average FeNO level higher than that of females, and FeNO levels increase with increasing age, weight and height, and decreasing FEF25-75% but not FVC or FEV1.Keywords: fractional exhaled nitric oxide, age, gender.
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Wilaiwan Khrisanapant (Khon Kaen, Thailand), Wilaiwan Khrisanapant, Tichanon Promsrisuk, Orapin Pasurivong, Watchara Boonsawat, Boonsong Patjanasoontorn, Burabha Pussadhamma, Paitoon Benjapornlert. Correlations between fractional exhaled nitric oxide and age and lung function in healthy Thai adults. Eur Respir J 2015; 46: Suppl. 59, 949
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