Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Citrus fruit consumption is inversely related to wheezing (Forastiere et al Thorax 2000 55:283),probably trhough antioxidant activity and histamine modulation. We investigated the effect of reported consumption of citrus fruit on respiratory parameters and oxidant status in 138 workers exposed to travertine dust and in 51 control subjects. We measured plasma glutathione (GLUT), total antioxidant status(TAS), reactive oxygen species (ROS), thiol groups(TH), respiratory symptoms and function and intake of citrus (Ci) and non citrus (Ni) fruits. In 83 workers we could also calculated the % decline of FEV1 in the previous 7 yrs. Ci was lower in case of diagnosis of asthma (1.00+1.1 vs 1.67+1.1 ; p <0.05), seasonal asthma (0.95+0.9 vs 1.70+1.2 ; p<0.01) and wheezing with dyspnoea (0.94+0.9 vs 1.70+1.2 ; p<0.01). Multivariate regression showed a positive independent association of Ci, but not of Ni, with FEV1/FVC (beta coefficient (b)=0.031 F=4.31), even after adjustment for other inversely related variables (age, smoking status, exposition to dust). Highest and lowest quartile of FEV1 decline significantly differed in Ci (1.05+0.9 vs 1.84+1.3 ;p<0.05). A non significant weak association between low Ci and low GLUT was observed. Our data confirm a protective effect of citrus fruit on asthma.

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Effect of citrus fruit consumption on asthma, airway obstruction and 7-year FEV1 decline in travertine workers. Eur Respir J 2002; 20: Suppl. 38, 3158

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