Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Exhaled carbon monoxide (ExCO) partly reflects endogenous production from heme catabolism by heme oxigenase (HE). HE activity and ExCO have been shown to increase in COPD. We investigated ExCO levels, lung function and symptoms, blood red cells, chemiluminescence (CL) and glutathione in 67 workers exposed to travertine dust and in 41 controls. We excluded smokers and subjects with ExCO >9. Respiratory data were collected by a questionnaire and spirometry. ExCO was measured by a MicroCO. ExCO was increased in never-smoking (NS) workers compared to NS controls (5.32±]1.6 vs 3.70±]1.6; p<0.01). Ex-smokers workers and controls did not differ. Glutathione was lower in workers (2.44+1.4 vs 5.33+2.9 μmol/L; p<0.0001).Workers showed increased levels of lucigenin CL without (0.82±]0.34 vs 0.66±]0.5 cps) and with PMA(1.42±]0.4 vs 1.12±]0.7 cps; p<0.01) and luminol CL after PMA (3.63±]1.2 vs 2.98±]1.5 cps; p<0.01). By multivariate analysis we found an independent positive correlation beteween ExCO and FEV1(%pred)(beta coefficient (b)=0.04, F=12.54), exposure to dust (b=0.68, F=4.50), and an inverse correlation with FEV1/FVC (b=-0.07, F=6.93) and glutathione (b=-0.13 ; F=4.66. No correlation with red cells parameters was found. ExCO depends on airflow, is increased by dust exposure and may be be a marker of oxidative stress.

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Increase of exhaled carbon monoxide in dust exposed workers: correlation with increased blood luminescence. Eur Respir J 2002; 20: Suppl. 38, 3157

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