Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

COPD characterized by an ongoing airway inflammation as a response of inhalation of smoking and other noxious agents. Although many studies have investigated the type of inflammation on the steady state of the disease, about the findings of the type of airway inflammation during the COPD exacerbation are few and controversial. The aim of this study was to investigate the possible involvement of CD8+ cells and their subpopulations in COPD exacerbation. Methods. A group of 10 COPD patients (68±]23 pack/years), aged 69±]7 years, FEV1 40±]14% pred, non-atopics participated in the study. Exacerbation was defined by the criteria ERS statement (Eur Respir J 1995;8:1398-1420). The subpopulation of CD4+ cells (Th1, and Th2), and CD8+ cells (Tc1 and Tc2) counts in spontaneous sputum on exacerbation and in induced sputum during remission using immunocytochemistry (trousse de dosage immunoenzymatique enzyme immunoassay kit for IL-8 and GM-CSF from Immunotech) were performed. Results. Statistical significant differences between exacerbation and steady state were found in the ratio CD4/CD8, p<0.04, median (range) 1.05 (0.9-1.5) vs .1.45 (0.9-1.9), as well as in the ratio Tc1/Tc2, p<0.02, median (range) 21.5 (12-32) vs. 44 (15-62). We conclude that an imbalance of T-lymphocytes CD4/CD8 ratio and the CD8+ cells subpopulation was detected during COPD exacerbation in comparison to steady state disease.

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M. Tsoumakidou, G. Chrysofakis, N. Tzanakis, E. Papadopouli, D. Kyriakou, N. M. Siafakas (Heraklion, Larissa, Greece). Possible involvement of CD8+ cells and their subpopulations in COPD exacerbations. Eur Respir J 2002; 20: Suppl. 38, 3156

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