Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

The aim of this study was to explore differences of neutrophilic inflammation between stable Chronic Obstructive Pulmonary Disease and exacerbated disease. Methods. We studied a group of 10 COPD patients (68±]23 pack/years), aged 69±]7 years, FEV1 40±]14( % of pred), non atopics, during an exacerbation and on stable period. Exacerbation was defined by the criteria of ERS statement (Eur Respir J 1995;8:1398-1420). Differential cell counts in spontaneous sputum MGG stained slides during exacerbation and during stable condition were performed. IL-8 and GM-CSF levels in sputum using by enzymatic immunoassay (trousse de dosage immunoenzymatique enzyme immunoassay kit for IL-8 and GM-CSF from Immunotech) were also measured. Results. Statistical significant differences between exacerbation and stable disease were found on the percentage of sputum neutrophils, median (range) (%) 98 (93-100) vs. 85(51-99) p<0.005, and in the concentration of IL-8 (pg/ml), median (range) 24770 (1484-48857) vs. 4947 (2179-37188), (p<0.03). No statistical significant difference was found in the concentration of GM-CSF (pg/ml), p=0.09, median (range) 110 (0-1010) vs. 36 (0-143) between exacerbation and steady state. Conclusion. Our results showed that along with increased neutrophils, the levels of IL-8 and not of GM-CSF are increased in sputum of patients in COPD exacerbation in comparison to stable condition.

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M. Tsoumakidou, G. Chrysofakis, N. Tzanakis, E. Papadopouli, N. M. Siafakas (Heraklion, Greece). Acceleration of neutrophilic inflammation during COPD exacerbation. Eur Respir J 2002; 20: Suppl. 38, 3155

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