Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Several bronchoconstrictor stimuli, including exercise (Persson 1993), allergens (Karitonov 1995), and viral infections (De Grouw 1998 ), have been shown to downregulate exhaled NO. We compared the of ultrasonically nebulized distilled water (UNDW), which is bronchospasmogenic, and of physiologic saline, which usually does not cause bronchoconstriction. We studied 10 asthmatic subjects( 6 females, mean age 43 ±] 14 , baseline FEV1 94 ±] 13% of predicted, 7 atopic), responsive to a preliminary challenge with UNDW. On two occasions, 2-5 days apart, each subject performed in randomised order a challenge with increasing doses of 1-3-7-15-31 ml UNDW, until a decrease in FEV1 of 20% or more was observed, or 8 ml saline 0.7%, through an ultrasonic nebulizer with an output of 2 ml/min. Exhaled NO was measured before challenge and after 2,15, 30, and 45 minutes during a slow VC maneuver with a costant expiratory flow against a resistance with a NOA 270 b chemioluminescence analyzer (Sievers), as the mean of 3 technically acceptable measurements. Inhalation of UNDW caused both bronchoconstriction (mean PD20 10 ±] 9 ml) and decrease in exhaled NO, while saline had no effect on both parameters

	UNDW		Saline
	FEV1	NO (ppm)	FEV1	NO
Baseline		26 ±] 10		27 ±] 11
2¢	-24 ±] 5%	19 ±] 8 **	-3 ±] 1%	26 ±] 6
15¢	-13 ±] 9 %	22 ±]8 *	-1 ±] 0.4%	26 ±] 8
30¢	-11 ±] 10%	24 ±] 9 *	+2 ±] 2%	25 ±] 5
45'	-4 ±]13	25 ±] 9	+2 ±]1%	28 ±] 12

Rating:

Share or cite this content

Citations should be made in the following way:
A. Vaghi, G. DeBernardi, N. Grassi, S. Capato, I. Pessina, P. Sestini (Garbagnate Milanese, Siena, Italy). Ultrasonic mist of distilled water but not saline reduces exhaled nitric oxide in asthma. Eur Respir J 2002; 20: Suppl. 38, 3152

Member's Comments

No comment yet.

Related content which might interest you: Warm air inhalation increases exhaled nitric oxide and carbon monixide levels in normal subjects Source: Eur Respir J 2003; 22: Suppl. 45, 414s Year: 2003 Experimental and theoretical impact of hypertonic saline induction on exhaled nitric oxide Source: International Congress 2017 – Lung function testing Year: 2017 Exhaled nitric oxide, methacoline and hypertonic saline inhalation in normal subjects Source: Eur Respir J 2001; 18: Suppl. 33, 164s Year: 2001 Effects on exhaled nitric oxide levels and lung function of ultrasonically nebulized hypertonic solution in cystic fibrosis Source: Eur Respir J 2003; 22: Suppl. 45, 231s Year: 2003 Nasal nitric oxide, exhaled nitric oxide and exhaled breath condensate pH measurements in children with allergic disease Source: Annual Congress 2008 - Clinical utility of exhaled nitric oxide measurement Year: 2008 No effect of breathing dry gas on exhaled nitric oxide concentration at rest Source: Annual Congress 2012 - Exhaled biomarkers in airway diseases Year: 2012 Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma Source: Eur Respir J 2002; 20: 108-111 Year: 2002 Increased exhaled nitric oxide among workers exposed to metalworking fluid aerosol Source: Annual Congress 2012 - Occupational asthma Year: 2012 The impact of hypertonic saline inhalation on nasal nitric oxide levels and mucociliary clearance Source: Annual Congress 2013 –Clinical physiology and functional imaging in health and disease Year: 2013 Association between mannitol dry powder challenge test results and fractional exhaled nitric oxide in children Source: Annual Congress 2008 - Assessment of inflammation, hyperresponsiveness and response to exercise in asthmatic children Year: 2008 Effect of caffeine on exhaled nitric oxide measurements in asthma Source: Eur Respir J 2003; 22: Suppl. 45, 180s Year: 2003 Exhaled nitric oxide concentration and exhaled breath condensate pH after hyperbaric oxygen exposure Source: Eur Respir J 2006; 28: Suppl. 50, 652s Year: 2006 Exhaled nitric oxide and exhaled breath condensate pH in severe refractory asthma Source: Annual Congress 2008 - Inflammatory biomarkers Year: 2008 Exhaled nitric oxide and bronchial responsiveness in subjects exposed to organic dust Source: Eur Respir J 2001; 18: Suppl. 33, 164s Year: 2001 Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust Source: Eur Respir J 2002; 20: 426-431 Year: 2002 Is exhaled nitric oxide a marker of air pollution effect? Source: Eur Respir J 2016; 47:1304-1306 Year: 2016 Exhaled nitric oxide and exhaled breath condensate pH in smoking asthma Source: Annual Congress 2009 - Airway inflammation and asthma control Year: 2009 Concentration of nitric oxide in exhaled air (eNO) in patients with sarcoidosis Source: Eur Respir J 2002; 20: Suppl. 38, 434s Year: 2002