Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Inhalation of ultrasonically nebulized distilled water (UNDW) but not saline causes a reduction in exhaled NO, probably associated to the bronchoconstrictor effect (Vaghi, ERS 2002). In this study we compared the effect on exhaled NO of a direct (methacholine, mch) and an indirect (UNDW) bronchoconstrictor stimuli. We studied 12 asthmatics (8 M, mean age 50 + 17 years, 7 atopic, FEV1 98.5 + 11.7 % of predicted, responsive to UNDW in a preliminary challenge. On two occasions, 2-5 days apart, the subjects performed a challenge with mch or UNDW challenge in random order. Both tests were interrupted when a decrease in FEV1 of 20% or more was reached. Exhaled NO was then recorded between 2 to 45' during a slow VC maneuver with a costant expiratory flow against a resistance with a NOA 270 b chemioluminescence analyzer (Sievers). Both stimuli caused a similar degree ofd reduction in FEV1 and in exhaled NO, suggesting that the latter is due in both cases to a reduction in bronchial caliber (Table: ** p<0.01; * p<0.05). These findings confirm the previous observations by Heidi et al (AJRCCM, May 1988) using histamine and hypertonic saline, respectively, as direct and indirect stimuli.

	UNDW		Methacholine
	FEV1	NO (ppb)	FEV1	NO
Baseline		28±]14		27±]13
2'	-24±]8%	20±]11 **	-22±]5%	19±]9**
15'	-11±]8%	23±]13**	-12±]8%	21±]11**
30'	-6±]8%	24±]12*	-7±]7%	24±]10*
45'	-2±]7%	27±]14	-1±]2%	25±]10

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Citations should be made in the following way:
A. Vaghi, G. DeBernardi, S. Capato, N. Grassi, I. Pessina, P. Sestini (Garbagnate Milanese, Siena, Italy). Effect of ultrasonically nebulized water- and methacholine-induced bronchoconstriction on exhaled NO in asthma. Eur Respir J 2002; 20: Suppl. 38, 3151

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