Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Bronchial hyperresponsiveness (BHR) is the main pathophysiological feature of asthma. Eosinophilic inflammation of airway is one of factors influencing BHR. The aim of the study was to evaluate bronchial responsiveness to methacholine and exercise and its relation to allergy parameters of asthma patients. Methods. 40 patients with steroid-naive asthma were examined. Bronchial responsiveness was tested with methacholine and exercise challenges. Patients were divided in two groups: exercise–induced asthma group – EIA(+) (n=21) and not exercise–induced asthma group – EIA(-) (n=19). Allergic status was determined by skin prick tests, peripheral blood and nasal secretion eosinophils count was evaluated. Results. All patients (100%) had increased bronchial responsiveness to methacholine, and 52.5% - to exercise. Methacholine provocative dose (PD₂₀) was lower (p=0.001) and blood eosinophils count higher (p=0.006) in the EIA(+) group, comparing with EIA(-) group. No statistical difference was estimated on nasal secretion eosinophils count between two groups. It was found significant correlation between blood eosinophils and PD₂₀ (p=0.003) and maximal fall of forced expiratory volume in 1 sec. after exercise challenge (ΔFEV₁) (p=0.03). No correlation was found between nasal secretion eosinophils count and PD₂₀ and ΔFEV₁. A significant correlation was evaluated between PD₂₀ and ΔFEV₁ (r= -0.426, p=0.048). Conclusions. Methacholine and exercise provoke bronchial obstruction by separate mechanisms in asthma, and eosinophils in peripheral blood, but not in nasal secretion, are correlated with BHR to these challenges.

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K. Malakauskas, I. Bajoriuniene (Kaunas, Lithuania). Bronchial hyperresponsiveness to methacholine and exercise, relation to allergy in asthma patients. Eur Respir J 2002; 20: Suppl. 38, 3150

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