Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Cold weather seems to be an asthma trigger in West Siberia because of its climate with long period of low temperatures. The aims of this study were: to investigate influence of cold air on the course of asthma in children and to find ways for making optimum rehabilitation programs. To study sensitiveness of bronchial receptors to cold air 420 schoolchildren with asthma were performed test with isocapnical cold air hyperventilation. The method of stepped cooling of inhaled air (-14[degree]C; -18[degree]C; -22[degree]C) allowed to reveal cold-induced bronchial hyperresponsiveness in 99 children (23,6%). We used this investigation as part of ISAAC study and found the higher prevalence of cold-induced bronchial hyperresponsiveness among children with first time diagnosed asthma than in patients with asthma diagnosed before (33,8% and 21,4% respectively). Among asthma exacerbation factors non-immune triggers were likely to play the main role. Indoors and ingestant allergens were the most important immune triggers. The schoolchildren with asthma on account of pollen allergen sensitization didn[scquote]t have sensitiveness of bronchial receptors to cold air. This study revealed features of asthma with cold-induced bronchial hyperresponsiveness: association with allergic rhinitis or/ and atopic dermatitis, importance of non-immune triggers, spontaneous termination of cold-induced bronchospasm.

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Citations should be made in the following way:
E. G. Kondiourina, T. N. Elkina, O. A. Boxler (Novosibirsk, Russia). Cold-induced hyperresponsiveness in childhood asthma. Eur Respir J 2002; 20: Suppl. 38, 3149

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