Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

(Background and objective) Bronchoprovocation with methacholine results in a significant fall in the arterial oxygen level. The aim of this study was to evaluate whether a fall in forced expiratory volume in one second (FEV1) or standardized partial expiratory flow at 40% FVC level (PEF40) are associated with a fall in oxygen saturation as measured by pulse oximetry (SpO2).
(Subjects and methods) 224 patients (118 men and 106 women), with a mean age of 56.4 (range 32-71) years undergoing diagnostic methacholine challenging in the pulmonary function laboratory of Kanazawa University Hospital were participated. Ascending concentrations of methacholine were inhaled for 2-min by tidal mouth breathing, and three attempts of partial and full flow-volume curves were carried out at 1-min intervals; the curve with the largest FVC was retained for analysis. SpO2 was measured immediately prior to each measurement of the flow-volume curve.
(Results) There were 56 non-responders (ΔFEV1<20%) and 167 responders. The ΔSpO2 was 3.19±]3.16% (Mean±]SD) in the responders and 2.40±]2.88% in non-responders (P=0.098). The ΔSpO2 was 6.29±]3.30% in 12 subjects (4 non-responders and 8 responders) who had received bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) and 2.80±]2.99 % in other subjects (p=0.0001), while the ΔFEV1 was not significantly different (21.02±]8.07% vs. 22.83±]10.33%), respectively. There was a significant correlation between ΔSpO2 and ΔPEF40 (r=0.219, p=0.002) in all subjects, but not between ΔSpO2 and ΔFEV1 (r=0.101, p=0.131).
(Conclusion) It is suggested that a fall in SpO2 during methacholine challenging was associated with a methacholine-induced fall in PEF40, but not FEV1.

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T. Kita, M. Fujimura, Y. Kondou, N. Katayama, M. Abo, M. Nishitsuji, Y. Yoshimi, S. Nomura, S. Nakao (Kanazawa, Japan). The monitoring of oxygen saturation during methacholine challenge test. Eur Respir J 2002; 20: Suppl. 38, 3146

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