Source: Annual Congress 2002 - Regulation of responsiveness and inflammation in airway disease
Disease area: Airway diseases

Abstract

Bronchial hyperresponsiveness and response to β₂-agonists might somehow be correlated in steroid-naive asthmatics having baseline values of FEV1 within the normal range. In 30 non-smoker asthmatics, steps I and II GINA (18 male, 12 female; Age 29 ±] 14 SD; FEV1 103 ±] 12 SD % pred.; FEV1/FVC 102 ±] 6 SD % pred.) we assessed the response to inhalation of albuterol, 200 mcg, in terms of FEV1 improvement (+ΔFEV1, %) and the bronchial hyperresponsiveness in terms of Provocative Dose (PD₂₀, mcg) and Response/Cumulative Dose Ratio (RCDR, -ΔFEV1/CD, %/log₁₀ mcg) by means challenge with methacholine. The two tests were performed in two different days, in a period not longer than a week in each patient. After administration of albuterol, FEV1 showed a significant improvement (5 ±] 3 % ±] SD, p<0.0001).The mean value of PD₂₀ was 556 ±] 407 SD mcg. We found significant correlations between +ΔFEV1 and PD₂₀ (r=0.62, p=0.0003) as well as +ΔFEV1 vs RCDR (r=0.54, p=0.0023) but not between +ΔFEV1 and its baseline value. We conclude that in patients with mild asthma having baseline values of FEV1 within the normal range, a large bronchial response to β₂-agonists seems to indicate the presence of high degree of bronchial hyperresponsiveness.

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Citations should be made in the following way:
M. Biagini, M. Rossi (Arezzo, Italy). Relationship between bronchial hyperresponsiveness and response to β₂-agonists in steroid-naïve patients with mild asthma. Eur Respir J 2002; 20: Suppl. 38, 3145

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